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GO:0070531

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description BRCA1-A complex
Full defintion A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
Subterm of

Relationships

The relationship of GO:0070531 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmah
PMID
NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.Wang B, Hurov K, Hofmann K, Elledge SJ
Genes Dev. 2009 Mar 15; 23 (6): 729–39.PMID: 19261749

The ability to sense and respond to DNA damage is critical to maintenance of genomic stability and the prevention of cancer. In this study, we employed a genetic screen to identify a gene, NBA1 (new component of the BRCA1 A complex), that is required for resistance to ionizing radiation. The NBA1 protein localizes to sites of DNA damage and is required for G2/M checkpoint control. Proteomic analysis revealed that NBA1 is a component of the BRCA1 A complex, which also contains Brca1/Bard1, Abra1, RAP80, BRCC36, and BRE. NBA1 is required to maintain BRE and Abra1 abundance and for the recruitment of BRCA1 to sites of DNA damage. In depth bioinformatics analysis revealed that the BRCA1 A complex bears striking similarities to the 19S proteasome complex. Furthermore, we show that four members of the BRCA1-A complex possess a polyubiquitin chain-binding capability, thus forming a complex that might facilitate the deubiquitinating activity of the deubiquitination enzyme BRCC36 or the E3 ligase activity of the BRCA1/BARD1 ligase. These findings provide a new perspective from which to view the BRCA1 A complex.

Associated Lotus transcripts 9

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v1785790.1
– Uncharacterized protein TCM_037260 [Theobroma cacao] gi|508782602|gb|EOY29858.1|
GO terms
3
Lj3g3v0075800.1
– Lys-63-specific deubiquitinase BRCC36 [Medicago truncatula] gi|357455111|ref|XP_003597836.1|
GO terms
5
Lj6g3v0328460.1
– Uncharacterized protein TCM_037260 [Theobroma cacao] gi|508782602|gb|EOY29858.1|
GO terms
3
Lj6g3v1692390.1
– PREDICTED: BRCA1-A complex subunit BRE-like isoform X2 [Cicer arietinum] gi|502080026|ref|XP_004486438.1|
GO terms
2
LotjaGi1g1v0366100.1
– BRISC and BRCA1-A complex member 1; TAIR: AT4G32960.1 BRISC/BRCA1-A complex protein; Swiss-Prot: sp|Q6DJG6|BABA1_XENLA BRISC and BRCA1-A complex member 1; TrEMBL-Plants: tr|I3SNG0|I3SNG0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0366100
GO terms
3
LotjaGi3g1v0011600.1
– Lys-63-specific deubiquitinase BRCC36; TAIR: AT1G80210.1 Mov34/MPN/PAD-1 family protein; Swiss-Prot: sp|Q4VA72|BRCC3_XENTR Lys-63-specific deubiquitinase BRCC36; TrEMBL-Plants: tr|C6T923|C6T923_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0011600
GO terms
5
LotjaGi3g1v0011600.3
– Lys-63-specific deubiquitinase BRCC36; TAIR: AT1G80210.1 Mov34/MPN/PAD-1 family protein; Swiss-Prot: sp|Q4VA72|BRCC3_XENTR Lys-63-specific deubiquitinase BRCC36; TrEMBL-Plants: tr|C6T923|C6T923_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0011600
GO terms
5
LotjaGi6g1v0275300.1
– BRCA1-A complex subunit BRE; TAIR: AT5G42470.1 BRCA1-A complex subunit BRE-like protein; Swiss-Prot: sp|Q568D5|BRE_DANRE BRCA1-A complex subunit BRE; TrEMBL-Plants: tr|I3SXL6|I3SXL6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275300
GO terms
2
LotjaGi6g1v0275300.2
– BRCA1-A complex subunit BRE; TAIR: AT5G42470.1 BRCA1-A complex subunit BRE-like protein; Swiss-Prot: sp|Q568D5|BRE_DANRE BRCA1-A complex subunit BRE; TrEMBL-Plants: tr|I3SXL6|I3SXL6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275300
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0070552
Cellular component BRISC complex 1 11.11