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IPR000132

Source: InterPro

Description

IPR000132 is a Nitrilase/cyanide hydratase, conserved site.

<p>This family includes both nitrilases and cyanide hydratase. Nitrilases ([ec:3.5.5.1]) are enzymes that convert nitriles into their corresponding acids and ammonia. They are widespread in microbes as well as in plants where they convert indole-3-acetonitrile to the hormone indole-3- acetic acid. A conserved cysteine has been shown [[cite:PUB00004812], [cite:PUB00002743]] to be essential for enzyme activity; it seems to be involved in a nucleophilic attack on the nitrile carbon atom. Cyanide hydratase ([ec:4.2.1.66]) converts HCN to formamide. In phytopathogenic fungi, it is used to avoid the toxic effect of cyanide released by wounded plants [[cite:PUB00000214]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016810
Molecular function Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
Lj0g3v0205259.1
– PREDICTED: bifunctional nitrilase/nitrile hydratase NIT4A-like [Glycine max] gi|356539229|ref|XP_003538102.1|
Domains
9
Lj3g3v2981810.1
– PREDICTED: bifunctional nitrilase/nitrile hydratase NIT4A-like [Glycine max] gi|356539229|ref|XP_003538102.1|
Domains
11
Lj3g3v2981810.3
– PREDICTED: bifunctional nitrilase/nitrile hydratase NIT4A-like [Glycine max] gi|356539229|ref|XP_003538102.1|
Domains
11
Lj3g3v2981810.4
– PREDICTED: bifunctional nitrilase/nitrile hydratase NIT4A-like [Glycine max] gi|356539229|ref|XP_003538102.1|
Domains
11
Lj3g3v2981830.1
– PREDICTED: bifunctional nitrilase/nitrile hydratase NIT4B-like [Vitis vinifera] gi|225464870|ref|XP_002272837.1|
Domains
10
LotjaGi3g1v0474600.1
– Nitrilase, putative; TAIR: AT5G22300.1 nitrilase 4; Swiss-Prot: sp|Q5QGZ8|NRL4A_LUPAN Bifunctional nitrilase/nitrile hydratase NIT4A; TrEMBL-Plants: tr|I3SLY0|I3SLY0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0474600
Domains
12
LotjaGi3g1v0474600.2
– Nitrilase, putative; TAIR: AT5G22300.1 nitrilase 4; Swiss-Prot: sp|Q5QGZ8|NRL4A_LUPAN Bifunctional nitrilase/nitrile hydratase NIT4A; TrEMBL-Plants: tr|I3SLY0|I3SLY0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0474600
Domains
12
LotjaGi3g1v0474600.3
– Nitrilase, putative; TAIR: AT5G22300.1 nitrilase 4; Swiss-Prot: sp|Q5QGZ8|NRL4A_LUPAN Bifunctional nitrilase/nitrile hydratase NIT4A; TrEMBL-Plants: tr|I3SLY0|I3SLY0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0474600
Domains
12
LotjaGi3g1v0474600.4
– Nitrilase, putative; TAIR: AT5G22300.1 nitrilase 4; Swiss-Prot: sp|Q5QGZ8|NRL4A_LUPAN Bifunctional nitrilase/nitrile hydratase NIT4A; TrEMBL-Plants: tr|I3SLY0|I3SLY0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0474600
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07564 CDD 1 11.11