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IPR000304 is a Pyrroline-5-carboxylate reductase-like.
<p>Pyrroline-5-carboxylate reductase (P5CR) ([ec:1.5.1.2]) [[cite:PUB00003735], [cite:PUB00001785]] is the enzyme that catalyses the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline. This enzyme is also able to convert delta-1-piperideine-6-carboxylate (P6C) into pipecolic acid [[cite:PUB00081473]]; this activity is part of pathway for the biosynthesis of the cyclic tetrapeptide apicidin F in the fungus Fusarium fujikuroi [[cite:PUB00081474]]. This entry also includes the pyrroline-5-carboxylate reductase ucsG from Acremonium sp., which is part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that is a strong telomerase inhibitor and displays potent antibacterial and antitumor properties [[cite:PUB00094509]]. This entry also includes Delta-1-pyrroline-5-carboxylate reductase kk1I, part of the gene cluster that mediates the biosynthesis of KK-1, a novel cyclic depsipeptide with 10 residues which is a promising active compound with high activity against many plant pathogens, especially Botrytis cinerea [[cite:PUB00153734], [cite:PUB00153735]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Pyrroline-5-carboxylate reductase activity | Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. | ||
| Biological process | Proline biosynthetic process | The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pyrroline-5-carboxylate reductase; TAIR: AT5G14800.1 pyrroline-5- carboxylate (P5C) reductase; Swiss-Prot: sp|Q04708|P5CR_PEA Pyrroline-5-carboxylate reductase; TrEMBL-Plants: tr|A0A1J7HNA1|A0A1J7HNA1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0665400 | 17 | ||
| – | Pyrroline-5-carboxylate reductase; TAIR: AT5G14800.1 pyrroline-5- carboxylate (P5C) reductase; Swiss-Prot: sp|Q04708|P5CR_PEA Pyrroline-5-carboxylate reductase; TrEMBL-Plants: tr|A0A1J7HNA1|A0A1J7HNA1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0665400 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00112 | TIGRFAM | 1 | 50.00 |