Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR000417

Source: InterPro

Description

IPR000417 is a Hydroxyethylthiazole kinase.

<p>Most microorganisms and plants can synthesise thiamin de novo [[cite:PUB00073181]]. In this de novo pathway, the thiazole and pyrimidine moieties of thiamin are made separately and coupled together to form thiamin phosphate. For the thiazole moiety, 4-methyl-5-(2-hydroxyethyl)thiazole (THZ), the key salvage step is phosphorylation to give 4-methyl-5-(2-phosphonooxyethyl)thiazole (THZ-P). The enzyme hydoxyethylthiazole kinase ([ec:2.7.1.50]) is responsible for this step. Hydoxyethylthiazole kinase is encoded by thiM in Escherichia coli [[cite:PUB00017550]] and other bacteria [[cite:PUB00101307], [cite:PUB00101306]], and by the C-terminal region of bifunctional proteins in some cases, such as Saccharomyces cerevisiae, in which the N-terminal domain corresponds to the bacterial thiamine-phosphate pyrophosphorylase ([ec:2.5.1.3]), ThiE [[cite:PUB00002882], [cite:PUB00058768]]. ThiM constitutes a potential target for pro-drug compounds for antibacterial drug development.</p> <p>The Arabidopsis and maize genomes encode homologues of ThiM [[cite:PUB00073180]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004417
Molecular function Hydroxyethylthiazole kinase activity Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+).
Subterm of
GO:0009228
Biological process Thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0260219.1
– PREDICTED: hydroxyethylthiazole kinase-like [Cicer arietinum] gi|502122428|ref|XP_004497741.1|
Domains
11
LotjaGi6g1v0012200.1
– Hydroxyethylthiazole kinase; TAIR: AT3G24030.1 hydroxyethylthiazole kinase family protein; Swiss-Prot: sp|Q9LIQ4|THIM_ARATH Hydroxyethylthiazole kinase; TrEMBL-Plants: tr|A0A151U2V3|A0A151U2V3_CAJCA Hydroxyethylthiazole kinase; Found in the gene: LotjaGi6g1v0012200
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd01170 CDD 1 50.00