Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR000421 is a Coagulation factor 5/8 C-terminal domain.
<p>Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is called F5/8 type C, FA58C, or C1/C2- like domain. In the Dictyostelium discoideum (Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins [[cite:PUB00004623], [cite:PUB00004819], [cite:PUB00001120]] In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells [[cite:PUB00000770]]. The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity [[cite:PUB00000771], [cite:PUB00002850]]. It forms an amphipathic α-helix, which binds to the membrane [[cite:PUB00000416]]. FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulphide bond [[cite:PUB00000383], [cite:PUB00005035], [cite:PUB00001468]]. A further disulphide bond is located near the C-terminal of the second FA58C domain in MFGM [swissprot:Q08431] [[cite:PUB00001468]].</p> <pre> +------------------------------------------------------------------------+ | +-+ | | | | | CxPLGxxQITASxxxxxRLxxxWxxxxWxxxxxxQGxxxxxxxxxxxxGNxxxxxxxxxxRxPxcxcLRxExGC 'C': conserved cysteine involved in a disulphide bond. 'c': cysteine involved in a disulphide bond in MFGM [swissprot:Q08431]. 'x': any amino acid. upper case letters: conserved residues. </pre>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Kelch-like protein [Medicago truncatula] gi|357490099|ref|XP_003615337.1| | 19 | ||
| – | BTB/POZ domain-containing protein; TAIR: AT2G30600.1 BTB/POZ domain-containing protein; Swiss-Prot: sp|Q8LEV3|Y2060_ARATH BTB/POZ domain-containing protein At2g30600; TrEMBL-Plants: tr|G7JYH5|G7JYH5_MEDTR BTB/POZ domain plant protein; Found in the gene: LotjaGi5g1v0000900 | 21 | ||
| – | BTB/POZ domain-containing protein; TAIR: AT2G30600.1 BTB/POZ domain-containing protein; Swiss-Prot: sp|Q8LEV3|Y2060_ARATH BTB/POZ domain-containing protein At2g30600; TrEMBL-Plants: tr|A0A0R0GGE3|A0A0R0GGE3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0000900 | 22 | ||
| – | BTB/POZ domain-containing protein; TAIR: AT2G30600.1 BTB/POZ domain-containing protein; Swiss-Prot: sp|Q8LEV3|Y2060_ARATH BTB/POZ domain-containing protein At2g30600; TrEMBL-Plants: tr|A0A0R0GGE3|A0A0R0GGE3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0000900 | 21 | ||
| – | BTB/POZ domain-containing protein; TAIR: AT2G30600.1 BTB/POZ domain-containing protein; Swiss-Prot: sp|Q8LEV3|Y2060_ARATH BTB/POZ domain-containing protein At2g30600; TrEMBL-Plants: tr|G7JYH5|G7JYH5_MEDTR BTB/POZ domain plant protein; Found in the gene: LotjaGi5g1v0000900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18445 | CDD | 1 | 20.00 |