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IPR000534

Source: InterPro

Description

IPR000534 is a Semialdehyde dehydrogenase, NAD-binding.

<p>The semialdehyde dehydrogenase family is found in N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase [[cite:PUB00016262]], an enzyme involved in the biosynthesis of various amino acids from aspartate. This family is also found in yeast and fungal Arg5,6 protein, which is cleaved into the enzymes N-acety-gamma-glutamyl-phosphate reductase and acetylglutamate kinase. These are also involved in arginine biosynthesis. All proteins in this entry contain a NAD binding region of semialdehyde dehydrogenase.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016620
Molecular function Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
Subterm of
GO:0051287
Molecular function NAD binding Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj4g3v3113380.1
– PREDICTED: aspartate-semialdehyde dehydrogenase-like [Glycine max] gi|356524624|ref|XP_003530928.1|
Domains
18
LotjaGi2g1v0008800.1
– N-acetyl-gamma-glutamyl-phosphate reductase; TAIR: AT2G19940.2 Putative N-acetyl-gamma-glutamyl-phosphate reductase; Swiss-Prot: sp|Q93Z70|ARGC_ARATH Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic; TrEMBL-Plants: tr|G7I708|G7I708_MEDTR N-acetyl-gamma-glutamyl-phosphate reductase; Found in the gene: LotjaGi2g1v0008800
Domains
17
LotjaGi4g1v0458700.1
– Aspartate-semialdehyde dehydrogenase, N-acetyl-gamma-glutamyl-phosphate reductase; TAIR: AT1G14810.1 semialdehyde dehydrogenase family protein; Swiss-Prot: sp|P49420|DHAS_PROMA Aspartate-semialdehyde dehydrogenase; TrEMBL-Plants: tr|I1KQD8|I1KQD8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0458700
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01296 TIGRFAM 1 33.33