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IPR000580 is a TSC22/Bun.
<p>This entry includes a group of eukaryotic proteins that are evolutionary related and involved in transcriptional regulation. These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerisation. Proteins included in this entry are:</p> <ul> <li>Vertebrate proteins TSC22 1-4 [[cite:PUB00001471], [cite:PUB00147007]], transcriptional regulators that act in different pathways, for instance, TSC22-1 acts on C-type natriuretic peptide (CNP) promoter [[cite:PUB00001471]], it also promotes CASP3-mediated apoptosis [[cite:PUB00151118]] and positively regulates TGF-beta signaling [[cite:PUB00151116]]; TSC22-3 (also known as DIP) protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 [[cite:PUB00147024]] and it also contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 [[cite:PUB00151117]].</li> <li>Drosophila protein bunched [[cite:PUB00001102]] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.</li> <li>Caenorhabditis elegans protein tsct-1 (also known as T18D3.7), whose function is unknown.</li> </ul>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA-binding transcription factor activity | A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: WEB family protein At5g16730, chloroplastic-like [Cicer arietinum] gi|502104777|ref|XP_004492647.1| | 5 | ||
| – | PREDICTED: WEB family protein At5g16730, chloroplastic-like [Cicer arietinum] gi|502104777|ref|XP_004492647.1| | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |