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IPR000872 is a Tafazzin.
<p>This entry includes tafazzin and its homologues, such as Taz1 from yeasts and N-acylphosphatidylethanolamine synthase from plants. Tafazzin is an enzyme involved in the cardiolipin remodelling pathway [[cite:PUB00070930], [cite:PUB00070931]]. The phospholipid cardiolipin is an important component of the inner mitochondrial membrane that is involved in mitochondrial energy production and apoptosis [[cite:PUB00070931]].</p> <p>In humans tafazzin is expressed at high levels in cardiac and skeletal muscle. As many as 10 isoforms can be present in different amounts in different tissues. Isoforms with hydrophobic N-termini are thought to be membrane anchored, while shorter forms, lacking the hydrophobic stretch, may be cytoplasmic (these latter are found in leukocytes and fibroblasts, but not in heart and skeletal muscle). A central hydrophilic domain may serve as an exposed loop that interacts with other proteins. Defects in the taz gene are the cause of Barth syndrome, a severe inherited disorder, often fatal in childhood. The disease is characterised by cardiac and skeletal myopathy, short stature and neutropenia [[cite:PUB00003900]].</p> <p>In flies tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine [[cite:PUB00070932]].</p> <p>Budding yeast Taz1 is a lyso-phosphatidylcholine acyltransferase that is required for normal phospholipid content of mitochondrial membranes, whose acyl specificity in the reaction relies on lipid chemical composition [[cite:PUB00070928], [cite:PUB00097835]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. | ||
| Molecular function | Transferase activity, transferring acyl groups | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: N-acylphosphatidylethanolamine synthase-like [Cicer arietinum] gi|502153842|ref|XP_004509481.1| | 4 | ||
| – | PREDICTED: N-acylphosphatidylethanolamine synthase-like [Cicer arietinum] gi|502153842|ref|XP_004509481.1| | 10 | ||
| – | Tafazzin [Medicago truncatula] gi|357511839|ref|XP_003626208.1| | 10 | ||
| – | Glycerol-3-phosphate 1-acyltransferase; TAIR: AT3G05510.1 Phospholipid/glycerol acyltransferase family protein; Swiss-Prot: sp|Q6IV76|TAZ_ERYPA Tafazzin; TrEMBL-Plants: tr|G7KXI7|G7KXI7_MEDTR Phospholipid/glycerol acyltransferase family protein; Found in the gene: LotjaGi1g1v0770600 | 9 | ||
| – | Phospholipid/glycerol acyltransferase family protein; TAIR: AT1G78690.1 Phospholipid/glycerol acyltransferase family protein; Swiss-Prot: sp|Q9ZV87|NAPES_ARATH N-acylphosphatidylethanolamine synthase; TrEMBL-Plants: tr|G7L7V8|G7L7V8_MEDTR Phospholipid/glycerol acyltransferase family protein; Found in the gene: LotjaGi4g1v0141400 | 9 | ||
| – | Phospholipid/glycerol acyltransferase family protein; TAIR: AT1G78690.1 Phospholipid/glycerol acyltransferase family protein; Swiss-Prot: sp|Q9ZV87|NAPES_ARATH N-acylphosphatidylethanolamine synthase; TrEMBL-Plants: tr|A0A0R0IAL1|A0A0R0IAL1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0141400 | 8 | ||
| – | Phospholipid/glycerol acyltransferase family protein; TAIR: AT1G78690.1 Phospholipid/glycerol acyltransferase family protein; Swiss-Prot: sp|Q9ZV87|NAPES_ARATH N-acylphosphatidylethanolamine synthase; TrEMBL-Plants: tr|G7L7V8|G7L7V8_MEDTR Phospholipid/glycerol acyltransferase family protein; Found in the gene: LotjaGi4g1v0141400 | 9 | ||
| – | Phospholipid/glycerol acyltransferase family protein; TAIR: AT1G78690.1 Phospholipid/glycerol acyltransferase family protein; Swiss-Prot: sp|Q9ZV87|NAPES_ARATH N-acylphosphatidylethanolamine synthase; TrEMBL-Plants: tr|A0A0R0IAL1|A0A0R0IAL1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0141400 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF69593 | SUPERFAMILY | 1 | 12.50 |