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IPR000889 is a Glutathione peroxidase.
<p>Glutathione peroxidase (GSHPx) ([ec:1.11.1.9]) is an enzyme that catalyses the reduction of hydroperoxides by glutathione [[cite:PUB00003890]]. Its main function is to protect against the damaging effect of endogenously formed hydroperoxides. In higher vertebrates, several forms of GSHPx are known, including a ubiquitous cytosolic form (GSHPx-1), a gastrointestinal cytosolic form (GSHPx-GI), a plasma secreted form (GSHPx-P), and an epididymal secretory form (GSHPx-EP). In mammals there are eight GPx, divided in two clusters, the classical GPx (GPx1, GPx2, GPx3, GPx5 and GPx6) and phospholipid hydroperoxide GPx (GPx4, GPx7 and GPx8). The classical GPx is multimeric (commonly tetrameric) and soluble, while the phospholipid hydroperoxide (PHGPx) is monomeric and often membrane-associated [[cite:PUB00095067]]. In addition to these characterised forms, the sequence of a protein of unknown function [[cite:PUB00004364]] has been shown to be evolutionary related to those of GSHPx's.</p> <p>In filarial nematode parasites, the major soluble cuticular protein (gp29) is a secreted GSHPx, which may provide a mechanism of resistance to the immune reaction of the mammalian host by neutralising the products of the oxidative burst of leukocytes [[cite:PUB00004788]]. The structure of bovine seleno-glutathione peroxidase has been determined [[cite:PUB00001337]]. The protein belongs to the α-β class, with a three layer(aba) sandwich architecture. The catalytic site of GSHPx contains a conserved residue which is either a cysteine or, in many eukaryotic GSHPx, a selenocysteine [[cite:PUB00000070]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. | ||
| Biological process | Response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable glutathione peroxidase 4-like [Cucumis sativus] gi|449444653|ref|XP_004140088.1| | 13 | ||
| – | Glutathione peroxidase 1 [Lotus japonicus] gi|37930463|gb|AAP69867.1| | 16 | ||
| – | PREDICTED: probable glutathione peroxidase 8-like [Glycine max] gi|356528242|ref|XP_003532714.1| | 13 | ||
| – | Glutathione peroxidase GSH-PX3 [Lotus japonicus] gi|32435788|gb|AAP81673.1| | 13 | ||
| – | PREDICTED: phospholipid hydroperoxide glutathione peroxidase, chloroplastic-like [Cicer arietinum] gi|502125101|ref|XP_004498798.1| | 16 | ||
| – | RecName: Full=Phospholipid hydroperoxide glutathione peroxidase, chloroplastic; Short=PHGPx; Flags: Precursorgi|2632109|emb|CAA04142.1| phospholipid glutathione peroxidase [Pisum sativum] gi|20138099|sp|O24296.1|GPX1_PEA | 20 | ||
| – | PREDICTED: probable glutathione peroxidase 4-like [Cicer arietinum] gi|502115537|ref|XP_004495228.1| | 10 | ||
| – | PREDICTED: probable glutathione peroxidase 4-like [Cicer arietinum] gi|502115537|ref|XP_004495228.1| | 15 | ||
| – | Glutathione peroxidase; TAIR: AT2G48150.1 glutathione peroxidase 4; Swiss-Prot: sp|Q8L910|GPX4_ARATH Probable glutathione peroxidase 4; TrEMBL-Plants: tr|I3SK85|I3SK85_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi1g1v0729600 | 16 | ||
| – | Glutathione peroxidase; TAIR: AT4G11600.1 glutathione peroxidase 6; Swiss-Prot: sp|Q06652|GPX4_CITSI Probable phospholipid hydroperoxide glutathione peroxidase; TrEMBL-Plants: tr|Q56VU1|Q56VU1_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi4g1v0425200 | 16 | ||
| – | Glutathione peroxidase; TAIR: AT1G63460.1 glutathione peroxidase 8; Swiss-Prot: sp|Q8LBU2|GPX8_ARATH Probable glutathione peroxidase 8; TrEMBL-Plants: tr|I3T8U1|I3T8U1_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi4g1v0425300 | 13 | ||
| – | Glutathione peroxidase; TAIR: AT2G43350.1 glutathione peroxidase 3; Swiss-Prot: sp|O22850|GPX3_ARATH Probable glutathione peroxidase 3, mitochondrial; TrEMBL-Plants: tr|I3SW73|I3SW73_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi4g1v0458000 | 18 | ||
| – | Glutathione peroxidase; TAIR: AT2G31570.1 glutathione peroxidase 2; Swiss-Prot: sp|Q06652|GPX4_CITSI Probable phospholipid hydroperoxide glutathione peroxidase; TrEMBL-Plants: tr|Q56VS3|Q56VS3_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi4g1v0458000 | 15 | ||
| – | Glutathione peroxidase; TAIR: AT2G25080.1 glutathione peroxidase 1; Swiss-Prot: sp|O24296|GPX1_PEA Phospholipid hydroperoxide glutathione peroxidase, chloroplastic; TrEMBL-Plants: tr|I3T0Y0|I3T0Y0_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi5g1v0053300 | 20 | ||
| – | Glutathione peroxidase; TAIR: AT2G48150.1 glutathione peroxidase 4; Swiss-Prot: sp|Q8L910|GPX4_ARATH Probable glutathione peroxidase 4; TrEMBL-Plants: tr|I3S0Y9|I3S0Y9_LOTJA Glutathione peroxidase; Found in the gene: LotjaGi5g1v0163900 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00340 | CDD | 1 | 6.67 |