Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR001095

Source: InterPro

Description

IPR001095 is a Acetyl-CoA carboxylase, alpha subunit.

<p>This entry contains the alpha subunit (Acetyl-coenzyme A carboxylase carboxyl transferase ACCA [ec:2.1.3.15]) of the acetyl coenzyme A carboxylase complex ([ec:6.4.1.2]). ACCA catalyses the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA, the first step in the synthesis of long-chain fatty acids. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [[cite:PUB00002735]]. The reaction involves two steps:</p> <p><reaction> Biotin carrier protein + ATP + HCO<sub>3</sub><sup>-</sup>->Carboxybiotin carrier protein + ADP + P<sub>i</sub> </reaction></p> <p><reaction> Carboxybiotin carrier protein + Acetyl-CoA ->Malonyl-CoA + Biotin carrier protein </reaction></p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003989
Molecular function Acetyl-CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
Subterm of
GO:0006633
Biological process Fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
Subterm of
GO:0009317
Cellular component Acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj0g3v0256879.2
– Alpha-carboxyltransferase 2 [Arachis hypogaea] gi|226425243|gb|ACO53621.1|
Domains
10
Lj1g3v2628750.3
– PREDICTED: acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic-like [Fragaria vesca subsp]. vesca] gi|470145526|ref|XP_004308388.1|
Domains
10
LotjaGi1g1v0473400.1
– Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; TAIR: AT2G38040.1 acetyl Co-enzyme a carboxylase carboxyltransferase alpha subunit; Swiss-Prot: sp|Q9LD43|ACCA_ARATH Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic; TrEMBL-Plants: tr|A0A151TBJ4|A0A151TBJ4_CAJCA Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Found in the gene: LotjaGi1g1v0473400
Domains
14
LotjaGi1g1v0473400.2
– Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; TAIR: AT2G38040.1 acetyl Co-enzyme a carboxylase carboxyltransferase alpha subunit; Swiss-Prot: sp|Q9LD43|ACCA_ARATH Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic; TrEMBL-Plants: tr|A0A151TBJ4|A0A151TBJ4_CAJCA Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Found in the gene: LotjaGi1g1v0473400
Domains
14
LotjaGi1g1v0572400.1
– Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; TAIR: AT2G38040.1 acetyl Co-enzyme a carboxylase carboxyltransferase alpha subunit; Swiss-Prot: sp|Q9LD43|ACCA_ARATH Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, chloroplastic; TrEMBL-Plants: tr|A0A1J7H3R8|A0A1J7H3R8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0572400
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 20.00