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IPR001190

Source: InterPro

Description

IPR001190 is a SRCR domain.

<p>The scavenger receptor cysteine-rich (SRCR) domain is an ancient and highly conserved domain of about 110 residues which is found in diverse secreted and cell-surface proteins, like the type I scavenger receptor, the speract receptor, CD5/Ly-1, CD6, or complement factor I [[cite:PUB00004717]]. Tandem repeats of SRCR domains are common in the membrane bound proteins. Most SRCR domains have six to eight cysteines that participate in intradomain disulfide bonds. SRCR domains have been subdivided into two groups, A and B, primarily on the differences in the spacing pattern between the cysteine residues [[cite:PUB00005429], [cite:PUB00003964]].</p> <p>Although the biochemical functions of SRCR domains have not been established with certainty, they are likely to mediate protein-protein interactions and ligand binding [[cite:PUB00005429], [cite:PUB00003964]].</p> <p>Determination of the crystal structure of the SRCR domain of M2BP reveals that the M2NP SRCR adopts a compact fold of approximate dimensions 22 x 26 x 30 Angstrom, organised around a curved six-stranded β-sheet cradling an alpha- helix [[cite:PUB00003964]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005044
Molecular function Scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
Subterm of
GO:0016020
Cellular component Membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj6g3v1162950.1
– Flavin-dependent monooxygenase 1 [Theobroma cacao] gi|508782921|gb|EOY30177.1|
Domains
11
LotjaGi6g1v0221300.1
– Flavin containing monooxygenase-like protein, putative; TAIR: AT1G19250.1 flavin-dependent monooxygenase 1; Swiss-Prot: sp|Q9LMA1|FMO1_ARATH Probable flavin-containing monooxygenase 1; TrEMBL-Plants: tr|A0A072V7P6|A0A072V7P6_MEDTR Flavin containing monooxygenase-like protein, putative; Found in the gene: LotjaGi6g1v0221300
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF51905 SUPERFAMILY 1 50.00