Description

IPR001282 is a Glucose-6-phosphate dehydrogenase.

<p>Glucose-6-phosphate dehydrogenase ([ec:1.1.1.49]) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [[cite:PUB00001763]]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells, and is critical for NADPH homeostasis and redox regulation [[cite:PUB00097192]]. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes with the distinctive one being chronic and drug- or food-induced hemolytic anemia, attributed to the inability to produce NADPH and withstand harmful oxidants in erythrocyte cells [[cite:PUB00097192], [cite:PUB00097191]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 30

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: