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IPR001349 is a Cytochrome c oxidase, subunit VIa.
<p>Cytochrome c oxidase ([ec:1.9.3.1]) is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen [[cite:PUB00000581]]. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane.</p> <p>In eukaryotes, in addition to the three large subunits, I, II and III, that form the catalytic centre of the enzyme complex, there are a variable number of small polypeptidic subunits. One of these subunits is known as VIa in vertebrates and fungi. Mammals have two tissue-specific isoforms of VIa, a liver (VIa-L) and a heart and skeletal muscle isoform (VIa-H). Mammalian VIa-H induces a slip in CcO (decrease in proton/electron stoichiometry) at high intramitochondrial ATP/ADP ratios, while VIa-L induces a permanent slip in CcO, depending on the presence of cardiolipin and palmitate [[cite:PUB00079537]]. Only one form is found in fish [[cite:PUB00000674]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Cytochrome-c oxidase activity | Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. | ||
| Cellular component | Mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. | ||
| Cellular component | Mitochondrial respiratory chain complex IV | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cytochrome c oxidase subunit 6a, mitochondrial-like [Cicer arietinum] gi|502152679|ref|XP_004509040.1| | 6 | ||
| – | Cytochrome c oxidase subunit 6a, mitochondrial; TAIR: AT4G37830.1 cytochrome c oxidase-like protein; Swiss-Prot: sp|Q9T070|COX6A_ARATH Cytochrome c oxidase subunit 6a, mitochondrial; TrEMBL-Plants: tr|I3S3T7|I3S3T7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0090600 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |