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IPR001412 is a Aminoacyl-tRNA synthetase, class I, conserved site.
<p>This entry represents a conserved sequence in their N-terminal section of class I aminoacyl-tRNA synthetases.</p> <p>The aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction [[cite:PUB00079872], [cite:PUB00079873]]. These proteins differ widely in size and oligomeric state, and have limited sequence homology [[cite:PUB00007191]]. The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric [[cite:PUB00006477]]. Class II aminoacyl-tRNA synthetases share an anti-parallel β-sheet fold flanked by α-helices [[cite:PUB00000386]], and are mostly dimeric or multimeric, containing at least three conserved regions [[cite:PUB00000723], [cite:PUB00005365], [cite:PUB00004391]]. However, tRNA binding involves an α-helical structure that is conserved between class I and class II synthetases. In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan, valine, and some lysine synthetases (non-eukaryotic group) belong to class I synthetases. The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, phenylalanine, proline, serine, threonine, and some lysine synthetases (non-archaeal group), belong to class-II synthetases. Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three subclasses, designated 1a, 1b, 1c and 2a, 2b, 2c [[cite:PUB00007363]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Nucleotide binding | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. | ||
Molecular function | Aminoacyl-tRNA ligase activity | Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. | ||
Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
Biological process | TRNA aminoacylation for protein translation | The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: valine--tRNA ligase-like [Cicer arietinum] gi|502091866|ref|XP_004489655.1| | 14 | ||
– | PREDICTED: tryptophanyl-tRNA synthetase-like [Glycine max] gi|356518366|ref|XP_003527850.1| | 22 | ||
– | PREDICTED: tyrosine--tRNA ligase-like [Cicer arietinum] gi|502129554|ref|XP_004500343.1| | 24 | ||
– | PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1| | 24 | ||
– | PREDICTED: arginine--tRNA ligase, cytoplasmic-like [Cicer arietinum] gi|502164060|ref|XP_004513035.1| | 24 | ||
– | PREDICTED: arginine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502164143|ref|XP_004513061.1| | 24 | ||
– | PREDICTED: arginine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502164143|ref|XP_004513061.1| | 15 | ||
– | PREDICTED: tyrosine--tRNA ligase-like [Cicer arietinum] gi|502129554|ref|XP_004500343.1| | 24 | ||
– | PREDICTED: glutamate--tRNA ligase, chloroplastic/mitochondrial-like [Cicer arietinum] gi|502155737|ref|XP_004510174.1| | 23 | ||
– | PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502147203|ref|XP_004506691.1| | 23 | ||
– | PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1| | 23 | ||
– | PREDICTED: isoleucine--tRNA ligase, cytoplasmic-like [Cicer arietinum] gi|502144299|ref|XP_004505648.1| | 24 | ||
– | PREDICTED: probable methionyl-tRNA synthetase-like [Glycine max] gi|356543424|ref|XP_003540160.1| | 30 | ||
– | PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1| | 35 | ||
– | PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1| | 34 | ||
– | PREDICTED: glutaminyl-tRNA synthetase-like isoform 1 [Glycine max] gi|356536302|ref|XP_003536678.1| | 28 | ||
– | PREDICTED: probable glutamyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356534931|ref|XP_003536004.1| | 33 | ||
– | PREDICTED: valyl-tRNA synthetase-like isoform 1 [Glycine max] gi|356535908|ref|XP_003536484.1| | 16 | ||
– | PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1| | 23 | ||
– | PREDICTED: isoleucine--tRNA ligase-like [Cicer arietinum] gi|502085158|ref|XP_004487851.1| | 28 | ||
– | Tryptophan-tRNA ligase; TAIR: AT2G25840.2 Nucleotidylyl transferase superfamily protein; Swiss-Prot: sp|Q8RXE9|SYWM_ARATH Tryptophan--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A151RK76|A0A151RK76_CAJCA Tryptophanyl-tRNA synthetase; Found in the gene: LotjaGi1g1v0409200 | 22 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529100 | 21 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529100 | 20 | ||
– | Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300 | 27 | ||
– | Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300 | 31 | ||
– | Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300 | 31 | ||
– | Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300 | 31 | ||
– | Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300 | 31 | ||
– | Arginine--tRNA ligase; TAIR: AT4G26300.1 Arginyl-tRNA synthetase, class Ic; Swiss-Prot: sp|O23247|SYRM_ARATH Arginine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|W0G2X0|W0G2X0_9FABA Arginyl-tRNA synthetase; Found in the gene: LotjaGi2g1v0226300 | 26 | ||
– | Arginine--tRNA ligase; TAIR: AT4G26300.5 Arginyl-tRNA synthetase, class Ic; Swiss-Prot: sp|O23247|SYRM_ARATH Arginine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UDN7|A0A072UDN7_MEDTR Cytoplasmic-like arginine-tRNA ligase; Found in the gene: LotjaGi2g1v0226700 | 26 | ||
– | Tyrosine--tRNA ligase; TAIR: AT3G02660.1 Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial; Swiss-Prot: sp|Q9M876|SYYM_ARATH Tyrosine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UXA5|A0A072UXA5_MEDTR Tyrosine--tRNA ligase; Found in the gene: LotjaGi3g1v0053200 | 24 | ||
– | Tryptophan-tRNA ligase; TAIR: AT3G04600.1 Nucleotidylyl transferase superfamily protein; Swiss-Prot: sp|Q9SR15|SYWC_ARATH Tryptophan--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A151TGC9|A0A151TGC9_CAJCA Tryptophanyl-tRNA synthetase, cytoplasmic; Found in the gene: LotjaGi3g1v0068700 | 14 | ||
– | Tryptophan-tRNA ligase; TAIR: AT3G04600.1 Nucleotidylyl transferase superfamily protein; Swiss-Prot: sp|Q9SR15|SYWC_ARATH Tryptophan--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A1J7GMT2|A0A1J7GMT2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0068700 | 14 | ||
– | Tryptophan-tRNA ligase; TAIR: AT3G04600.1 Nucleotidylyl transferase superfamily protein; Swiss-Prot: sp|Q9SR15|SYWC_ARATH Tryptophan--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A1J7GMT2|A0A1J7GMT2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0068700 | 17 | ||
– | Glutamate--tRNA ligase; TAIR: AT5G64050.1 glutamate tRNA synthetase; Swiss-Prot: sp|Q9FEA2|SYEM_ARATH Glutamate--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|V7ALD7|V7ALD7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0075100 | 25 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484200 | 20 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484200 | 20 | ||
– | Isoleucine-tRNA ligase; TAIR: AT4G10320.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|F4JLM5|SYIC_ARATH Isoleucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0S3SEB7|A0A0S3SEB7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0535700 | 23 | ||
– | Methionine-tRNA ligase, putative; TAIR: AT4G13780.1 methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS; Swiss-Prot: sp|Q9ZTS1|SYM_ORYSJ Probable methionine--tRNA ligase; TrEMBL-Plants: tr|A0A0B2SPF8|A0A0B2SPF8_GLYSO Putative methionine--tRNA ligase; Found in the gene: LotjaGi3g1v0538600 | 32 | ||
– | Methionine-tRNA ligase, putative; TAIR: AT4G13780.1 methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS; Swiss-Prot: sp|Q9ZTS1|SYM_ORYSJ Probable methionine--tRNA ligase; TrEMBL-Plants: tr|A0A0R0H9H8|A0A0R0H9H8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538600 | 24 | ||
– | Methionine-tRNA ligase, putative; TAIR: AT4G13780.1 methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS; Swiss-Prot: sp|Q9ZTS1|SYM_ORYSJ Probable methionine--tRNA ligase; TrEMBL-Plants: tr|A0A0R0H0Q5|A0A0R0H0Q5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538600 | 24 | ||
– | Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JJA8|G7JJA8_MEDTR Leucyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0011900 | 35 | ||
– | Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JJA8|G7JJA8_MEDTR Leucyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0011900 | 35 | ||
– | Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KNG6|I1KNG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0011900 | 29 | ||
– | Glutamine--tRNA ligase; TAIR: AT1G25350.1 glutamine-tRNA ligase, putative / glutaminyl-tRNA synthetase, putative / GlnRS; Swiss-Prot: sp|P52780|SYQ_LUPLU Glutamine--tRNA ligase; TrEMBL-Plants: tr|A0A0B2PPT7|A0A0B2PPT7_GLYSO Glutamine--tRNA ligase; Found in the gene: LotjaGi4g1v0303500 | 29 | ||
– | Glutamate--tRNA ligase; TAIR: AT5G26710.1 Glutamyl/glutaminyl-tRNA synthetase, class Ic; Swiss-Prot: sp|O82462|SYEC_ARATH Glutamate--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0L9TZ06|A0A0L9TZ06_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0005200 | 27 | ||
– | Glutamate--tRNA ligase; TAIR: AT5G26710.1 Glutamyl/glutaminyl-tRNA synthetase, class Ic; Swiss-Prot: sp|O82462|SYEC_ARATH Glutamate--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0L9TZ06|A0A0L9TZ06_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0235000 | 31 | ||
– | Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000 | 27 | ||
– | Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000 | 27 | ||
– | Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000 | 33 | ||
– | Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000 | 26 | ||
– | Tyrosine--tRNA ligase; TAIR: AT3G02660.1 Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial; Swiss-Prot: sp|Q9M876|SYYM_ARATH Tyrosine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072UXA5|A0A072UXA5_MEDTR Tyrosine--tRNA ligase; Found in the gene: LotjaGi6g1v0104800 | 24 | ||
– | Tyrosine--tRNA ligase; TAIR: AT3G02660.1 Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial; Swiss-Prot: sp|Q9M876|SYYM_ARATH Tyrosine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V2K0|A0A072V2K0_MEDTR Tyrosine--tRNA ligase; Found in the gene: LotjaGi6g1v0104800 | 23 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700 | 20 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700 | 20 | ||
– | Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700 | 20 | ||
– | Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900 | 29 | ||
– | Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900 | 28 | ||
– | Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900 | 27 | ||
– | Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 1.67 |