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IPR001613 is a Flavin amine oxidase.
<p>Monoamine oxidases (MAO) A and B are encoded by two genes derived from a common ancestral gene [[cite:PUB00003462]]. The enzymes catalyse the oxidative deamination of biogenic and xenobiotic amines and have important roles in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues [[cite:PUB00003451]]. MAO-A preferentially oxidises biogenic amines such as 5-hydroxytryptamine, norepinephrine and epinephrine. MAO-A deficiency has been linked to Brunner's syndrome, a form of X-linked nondysmorphic mild mental retardation [[cite:PUB00003451]].</p> <p>The protein contains two similarly-sized subunits, one of which contains covalently-bound flavin adenine dinucleotide (FAD). The FAD binding site lies near the C terminus; at the N terminus are features characteristic of the ADP-binding fold, suggesting that this region is also involved in FAD binding [[cite:PUB00003451]]. The A and B forms of the enzyme share 70% sequence identity; both contain the pentapeptide Ser-Gly-Gly-Cys-Tyr, the cysteine of which binds FAD [[cite:PUB00004658]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: polyamine oxidase 1-like [Cicer arietinum] gi|502128056|ref|XP_004499921.1| | 14 | ||
| – | PREDICTED: probable polyamine oxidase 2-like [Glycine max] gi|356567482|ref|XP_003551948.1| | 10 | ||
| – | Amine oxidase, putative; TAIR: AT2G43020.1 polyamine oxidase 2; Swiss-Prot: sp|Q9SKX5|PAO2_ARATH Probable polyamine oxidase 2; TrEMBL-Plants: tr|G7KD02|G7KD02_MEDTR Polyamine oxidase-like protein; Found in the gene: LotjaGi1g1v0046900 | 11 | ||
| – | Polyamine oxidase, putative; TAIR: AT5G13700.1 polyamine oxidase 1; Swiss-Prot: sp|Q9FNA2|PAO1_ARATH Polyamine oxidase 1; TrEMBL-Plants: tr|A0A151QV27|A0A151QV27_CAJCA Polyamine oxidase 1; Found in the gene: LotjaGi3g1v0120100 | 13 | ||
| – | Amine oxidase, putative; TAIR: AT1G65840.1 polyamine oxidase 4; Swiss-Prot: sp|Q8H191|PAO4_ARATH Probable polyamine oxidase 4; TrEMBL-Plants: tr|A0A0S3S5L6|A0A0S3S5L6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0050700 | 11 | ||
| – | Amine oxidase, putative; TAIR: AT2G43020.1 polyamine oxidase 2; Swiss-Prot: sp|Q9SKX5|PAO2_ARATH Probable polyamine oxidase 2; TrEMBL-Plants: tr|I1N129|I1N129_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0184500 | 11 | ||
| – | Amine oxidase, putative; TAIR: AT2G43020.1 polyamine oxidase 2; Swiss-Prot: sp|Q9SKX5|PAO2_ARATH Probable polyamine oxidase 2; TrEMBL-Plants: tr|A0A072UW35|A0A072UW35_MEDTR Polyamine oxidase-like protein; Found in the gene: LotjaGi6g1v0184500 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54373 | SUPERFAMILY | 1 | 14.29 |