Description

IPR001930 is a Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase.

<p>This group of metallopeptidases belong to the MEROPS peptidase family M1 (clan MA(E)), the type example being aminopeptidase N from Homo sapiens (Human). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA.</p> <p>Membrane alanine aminopeptidase ([ec:3.4.11.2]) is part of the HEXXH⁺E group; it consists entirely of aminopeptidases, spread across a wide variety of species [[cite:PUB00003579]]. Functional studies show that CD13/APN catalyses the removal of single amino acids from the amino terminus of small peptides and probably plays a role in their final digestion; one family member (leukotriene-A4 hydrolase) is known to hydrolyse the epoxide leukotriene-A4 to form an inflammatory mediator [[cite:PUB00003579]]. This hydrolase has been shown to have aminopeptidase activity [[cite:PUB00000193]], and the zinc ligands of the M1 family were identified by site-directed mutagenesis on this enzyme [[cite:PUB00003579]] CD13 participates in trimming peptides bound to MHC class II molecules [[cite:PUB00008035]] and cleaves MIP-1 chemokine, which alters target cell specificity from basophils to eosinophils [[cite:PUB00008036]]. CD13 acts as a receptor for specific strains of RNA viruses (coronaviruses) which cause a relatively large percentage of upper respiratory tract infections.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: