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IPR001948 is a Peptidase M18.
<p>This group of metallopeptidases belong to the MEROPS peptidase family M18, (clan MH). The proteins have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His. The catalysed reaction involves the release of an N-terminal aminoacid, usually neutral or hydrophobic, from a polypeptide [[cite:PUB00003579]].</p> <p>The type example is aminopeptidase I from Saccharomyces cerevisiae (Baker's yeast), the sequence of which has been deduced, and the mature protein shown to consist of 469 amino acids [[cite:PUB00002544]]. A 45-residue presequence contains both positively- and negatively-charged and hydrophobic residues, which could be arranged in an N-terminal amphiphilic α-helix [[cite:PUB00002544]]. The presequence differs from signal sequences that direct proteins across bacterial plasma membranes and endoplasmic reticulum or into mitochondria. It is unclear how this unique presequence targets aminopeptidase I to yeast vacuoles, and how this sorting utilises classical protein secretory pathways [[cite:PUB00002544]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. | ||
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable aspartyl aminopeptidase-like [Cicer arietinum] gi|502130478|ref|XP_004500663.1| | 12 | ||
| – | PREDICTED: probable aspartyl aminopeptidase-like [Cicer arietinum] gi|502118298|ref|XP_004496198.1| | 11 | ||
| – | Aspartyl aminopeptidase-like protein, putative; TAIR: AT5G60160.1 Zn-dependent exopeptidases superfamily protein; Swiss-Prot: sp|B9RAJ0|DNPEP_RICCO Probable aspartyl aminopeptidase; TrEMBL-Plants: tr|I3T0P0|I3T0P0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0236300 | 12 | ||
| – | Aspartyl aminopeptidase; TAIR: AT5G04710.1 Zn-dependent exopeptidases superfamily protein; Swiss-Prot: sp|B9RAJ0|DNPEP_RICCO Probable aspartyl aminopeptidase; TrEMBL-Plants: tr|A0A0L9TZ40|A0A0L9TZ40_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0267400 | 11 | ||
| – | Aspartyl aminopeptidase; TAIR: AT5G04710.1 Zn-dependent exopeptidases superfamily protein; Swiss-Prot: sp|B9RAJ0|DNPEP_RICCO Probable aspartyl aminopeptidase; TrEMBL-Plants: tr|A0A0L9TZ40|A0A0L9TZ40_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0267400 | 11 | ||
| – | Aspartyl aminopeptidase; TAIR: AT5G04710.1 Zn-dependent exopeptidases superfamily protein; Swiss-Prot: sp|B9RAJ0|DNPEP_RICCO Probable aspartyl aminopeptidase; TrEMBL-Plants: tr|A0A0L9TZ40|A0A0L9TZ40_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0267400 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05658 | CDD | 1 | 16.67 |