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IPR001977 is a Dephospho-CoA kinase.
<p>This family contains Dephospho-coenzyme A kinase (DPCK, [ec:2.7.1.24]), which catalyzes the final step in dephosphocoenzyme A (dCoA) biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor.</p> <p>The crystal structures of a number of the proteins in this entry have been determined, including the structure of the protein from Haemophilus influenzae to 2.0-A resolution in a comlex with ATP. The protein consists of three domains: the nucleotide-binding domain with a five-stranded parallel β-sheet, the substrate-binding α-helical domain, and the lid domain formed by a pair of α-helices; the overall topology of the protein resembles the structures of other nucleotide kinases [[cite:PUB00026419]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Dephospho-CoA kinase activity | Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+). | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Biological process | Coenzyme A biosynthetic process | The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dephospho-CoA kinase-like [Cicer arietinum] gi|502112521|ref|XP_004494358.1| | 10 | ||
| – | Dephospho-CoA kinase; TAIR: AT2G27490.1 dephospho-CoA kinase family; Swiss-Prot: sp|Q9ZQH0|COAE_ARATH Dephospho-CoA kinase; TrEMBL-Plants: tr|I3SRY8|I3SRY8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0766500 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02022 | CDD | 1 | 50.00 |