Description

IPR002113 is a ADP/ATP carrier protein, eukaryotic type.

<p>A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [[cite:PUB00005351], [cite:PUB00001005], [cite:PUB00005084], [cite:PUB00003301], [cite:PUB00097195]]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.</p> <p>Sequence analysis of selected members of the carrier protein family has suggested the presence of six transmembrane (TM) domains, with varying degrees of sequence conservation and hydrophilicity [[cite:PUB00001005]]. The TM regions, and adjacent hydrophilic loops, are more highly conserved than other regions of the proteins [[cite:PUB00001005]]. All members of the family appear to consist of a tripartite structure, each of the repeated segments being ~100 residues in length [[cite:PUB00001005]]. Each repeat contains two TM domains, the first being more hydrophobic, with conserved glycyl and prolyl residues. Five of the six TM domains are followed by the conserved sequence (D/E)-Hy(K/R), where -denotes any residue and Hy is a hydrophobic position [[cite:PUB00001005]].</p> <p>Mitochondrial ADP/ATP translocase, an abundant component of the inner membrane, carries ATP from the matrix into the inter-membrane space and transports ADP back [[cite:PUB00097195], [cite:PUB00003243]]. The protein is an integral membrane protein that functions as a homodimer.</p> <p>Mutations of the human ADP/ATP translocase 1 (also known as SLC25A4) gene cause mitochondrial diseases, such as PEOA2 and MTDPS12B [[cite:PUB00094737]].</p> <p>This family contains proteins found in eucaryotes.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 38

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: