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IPR002167 is a Solute carrier family 25 member 16-like.
<p>This family includes a variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [[cite:PUB00005351], [cite:PUB00001005], [cite:PUB00005084], [cite:PUB00003301]]. Such proteins include: ADP, ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Solute carrier family 25 member 16 (SLC25A16, also known as Graves disease carrier protein, GDC); yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.</p> <p>GDC, which belongs to the mitochondrial metabolite carrier family [[cite:PUB00001005], [cite:PUB00003712]], is required for the accumulation of coenzyme A in the mitochondrial matrix [[cite:PUB00101072]]. The protein is recognised by IgG from patients with active Graves disease. It is an integral membrane protein thought to reside in the inner mitochondrial membrane. The predicted amino acid sequence of 348 residues comprises three similar domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Mitochondrial carrier protein-like; TAIR: AT4G26180.1 Mitochondrial substrate carrier family protein; Swiss-Prot: sp|Q01888|GDC_BOVIN Graves disease carrier protein; TrEMBL-Plants: tr|A0A151RGT0|A0A151RGT0_CAJCA Graves disease carrier protein; Found in the gene: LotjaGi2g1v0231400 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF103506 | SUPERFAMILY | 1 | 100.00 |