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IPR002207 is a Class I peroxidase.
<p>Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. They are found in bacteria, fungi, plants and animals. On the basis of sequence similarity, fungal, plant and bacterial peroxidases can be viewed as members of a superfamily consisting of 3 major classes. Class I, the intracellular peroxidases, includes yeast cytochrome c peroxidase (CCP), ascorbate peroxidase (AP) and bacterial catalase-peroxidases [[cite:PUB00053582]].</p> <p>In chloroplasts of higher plants, oxygen consumption in the absence of electron acceptors is accompanied by production of H2O2 and activated forms of oxygen. Chloroplasts contain several protective systems (such as superoxide dismutase (SOD), alpha-tocopherol and carotenoids), which are effective against various forms of activated oxygen. However, they lack catalase, and the disposal of H2O2 is accomplished by other means.</p> <p>Ascorbic acid is a strong antioxidant that is effective in scavenging superoxide (O2-'), hydroxyl (OH') radicals and singlet oxygen. It can also remove H2O2 in the following reaction:</p><reaction> Ascorbate + H2O2 -->dehydroascorbate + 2 H2O</reaction><p>Ascorbate peroxidase (AP) is the main enzyme responsible for hydrogen peroxide removal in the chloroplasts and cytosol of higher plants.</p> <p>The 3D structure of pea cytosolic ascorbate peroxidase has an overall fold virtually identical to that of CCP [[cite:PUB00000418]]. The protein consists of 2 all-alpha domains, between which is embedded the haem group. The most pronounced difference between the AP and CCP structures is the absence of an antiparallel β-hairpin between the G and H helices in the AP molecule.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Peroxidase activity | Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. | ||
| Biological process | Response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. | ||
| Molecular function | Heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peroxidase 15-like [Glycine max] gi|356555867|ref|XP_003546251.1| | 17 | ||
| – | PREDICTED: thylakoid lumenal 29 kDa protein, chloroplastic-like isoform X1 [Cicer arietinum] gi|502095135|ref|XP_004490382.1| | 18 | ||
| – | PREDICTED: L-ascorbate peroxidase S, chloroplastic/mitochondrial-like isoform X2 [Cicer arietinum] gi|502135885|ref|XP_004502487.1| | 16 | ||
| – | PREDICTED: L-ascorbate peroxidase T, chloroplastic-like isoform 2 [Glycine max] gi|356515910|ref|XP_003526640.1| | 20 | ||
| – | Ascorbate peroxidase 6 [Theobroma cacao] gi|508782223|gb|EOY29479.1| | 17 | ||
| – | PREDICTED: L-ascorbate peroxidase 3, peroxisomal [Glycine max] gi|356538634|ref|XP_003537806.1| | 21 | ||
| – | Peroxidase; TAIR: AT1G77490.1 thylakoidal ascorbate peroxidase; Swiss-Prot: sp|Q42593|APXT_ARATH L-ascorbate peroxidase T, chloroplastic; TrEMBL-Plants: tr|I1JZ46|I1JZ46_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0261800 | 16 | ||
| – | Peroxidase; TAIR: AT1G77490.1 thylakoidal ascorbate peroxidase; Swiss-Prot: sp|Q42593|APXT_ARATH L-ascorbate peroxidase T, chloroplastic; TrEMBL-Plants: tr|I1JZ45|I1JZ45_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0261800 | 20 | ||
| – | Peroxidase; TAIR: AT4G08390.1 stromal ascorbate peroxidase; Swiss-Prot: sp|Q42592|APXS_ARATH L-ascorbate peroxidase S, chloroplastic/mitochondrial; TrEMBL-Plants: tr|K7KM65|K7KM65_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0261800 | 22 | ||
| – | Peroxidase; TAIR: AT4G32320.1 ascorbate peroxidase 6; Swiss-Prot: sp|Q8GY91|APX6_ARATH Putative L-ascorbate peroxidase 6; TrEMBL-Plants: tr|I1K8U6|I1K8U6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0383600 | 17 | ||
| – | Ascorbate peroxidase; TAIR: AT1G07890.1 ascorbate peroxidase 1; Swiss-Prot: sp|P48534|APX1_PEA L-ascorbate peroxidase, cytosolic; TrEMBL-Plants: tr|G7JRI5|G7JRI5_MEDTR L-ascorbate peroxidase; Found in the gene: LotjaGi2g1v0364900 | 18 | ||
| – | Peroxidase family protein; TAIR: AT4G35000.1 ascorbate peroxidase 3; Swiss-Prot: sp|Q42564|APX3_ARATH L-ascorbate peroxidase 3, peroxisomal; TrEMBL-Plants: tr|G7JXJ2|G7JXJ2_MEDTR L-ascorbate peroxidase; Found in the gene: LotjaGi2g1v0380000 | 22 | ||
| – | Peroxidase family protein; TAIR: AT4G35000.1 ascorbate peroxidase 3; Swiss-Prot: sp|Q42564|APX3_ARATH L-ascorbate peroxidase 3, peroxisomal; TrEMBL-Plants: tr|I3T173|I3T173_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0521300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00691 | CDD | 1 | 7.69 |