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IPR002468 is a Peptidase M24A, methionine aminopeptidase, subfamily 2.
<p>This group of metallopeptidases belong to MEROPS peptidase family M24 (clan MG), subfamily M24A.</p> <p>Methionine aminopeptidase ([ec:3.4.11.18]) (MAP) catalyses the hydrolytic cleavage of the N-terminal methionine from newly synthesised polypeptides if the penultimate amino acid is small, with different tolerance to Val and Thr at this position [[cite:PUB00070140]]. All MAP studied to date are monomeric proteins that require cobalt ions for activity. Two subfamilies of MAP enzymes are known to exist [[cite:PUB00004871], [cite:PUB00005454]]. While being evolutionary related, they only share a limited amount of sequence similarity mostly clustered around the residues shown, in the Escherichia coli MAP [[cite:PUB00000379]], to be involved in cobalt-binding. The first family consists of enzymes from prokaryotes as well as eukaryotic MAP-1 ([interpro:IPR002467]), while the second group is made up of archaeal MAP and eukaryotic MAP-2 [[cite:PUB00017444]] and includes proteins which do not seem to be MAP, but that are clearly evolutionary related such as mouse proliferation-associated protein 1 and fission yeast curved DNA-binding protein.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. | ||
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
| Molecular function | Metalloexopeptidase activity | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: methionine aminopeptidase 2B-like [Glycine max] gi|356573919|ref|XP_003555103.1| | 18 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|A0A151RPI8|A0A151RPI8_CAJCA Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 20 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|A0A151RPI8|A0A151RPI8_CAJCA Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 20 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|K7MVR5|K7MVR5_SOYBN Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 19 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|K7MVR5|K7MVR5_SOYBN Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 19 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|K7MVR5|K7MVR5_SOYBN Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 19 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|K7MVR5|K7MVR5_SOYBN Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 19 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|K7MVR5|K7MVR5_SOYBN Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 19 | ||
| – | Methionine aminopeptidase 2; TAIR: AT3G59990.1 methionine aminopeptidase 2B; Swiss-Prot: sp|Q56Y85|MAP22_ARATH Methionine aminopeptidase 2B; TrEMBL-Plants: tr|K7MVR5|K7MVR5_SOYBN Methionine aminopeptidase 2; Found in the gene: LotjaGi6g1v0067300 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01088 | CDD | 1 | 11.11 |