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IPR002469 is a Dipeptidylpeptidase IV, N-terminal domain.
<p>This domain defines serine peptidases belonging to MEROPS peptidase family S9 (clan SC), subfamily S9B (dipeptidyl-peptidase IV). The protein fold of the peptidase domain for members of this family resembles that of serine carboxypeptidase D, the type example of clan SC. This domain is an alignment of the region to the N-terminal side of the active site, which is found in [interpro:IPR001375].</p> <p>Dipeptidyl-peptidase IV ([ec:3.4.14.5]) is also called adenosine deaminase-binding protein (ADA-binding protein) or CD26. The exopeptidase cleaves off N-terminal X-Pro or X-Ala dipeptides from polypeptides (dipeptidyl peptidase IV activity). It serves as the costimulatory molecule in T cell activation and is an associated marker of autoimmune diseases, adenosine deaminase-deficiency and HIV pathogenesis [[cite:PUB00075598], [cite:PUB00075599], [cite:PUB00075601]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dipeptidyl peptidase 8-like [Glycine max] gi|356516055|ref|XP_003526712.1| | 12 | ||
| – | Dipeptidyl peptidase; TAIR: AT5G24260.1 prolyl oligopeptidase family protein; Swiss-Prot: sp|Q6F3I7|DAP4_PSEMX Dipeptidyl aminopeptidase 4; TrEMBL-Plants: tr|A0A0B2QIB0|A0A0B2QIB0_GLYSO Dipeptidyl peptidase 8; Found in the gene: LotjaGi1g1v0285400 | 13 | ||
| – | Dipeptidyl peptidase; TAIR: AT5G24260.1 prolyl oligopeptidase family protein; Swiss-Prot: sp|Q6F3I7|DAP4_PSEMX Dipeptidyl aminopeptidase 4; TrEMBL-Plants: tr|A0A0B2QIB0|A0A0B2QIB0_GLYSO Dipeptidyl peptidase 8; Found in the gene: LotjaGi1g1v0285400 | 12 | ||
| – | Dipeptidyl peptidase; TAIR: AT5G24260.1 prolyl oligopeptidase family protein; Swiss-Prot: sp|Q6F3I7|DAP4_PSEMX Dipeptidyl aminopeptidase 4; TrEMBL-Plants: tr|A0A0B2QIB0|A0A0B2QIB0_GLYSO Dipeptidyl peptidase 8; Found in the gene: LotjaGi1g1v0285400 | 13 | ||
| – | Protein tolB; TAIR: AT4G01870.2 tolB protein-like protein; Swiss-Prot: sp|Q3A097|TOLB_PELCD Protein TolB; TrEMBL-Plants: tr|A0A0R0J475|A0A0R0J475_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0070500 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF82171 | SUPERFAMILY | 1 | 20.00 |