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IPR002472

Source: InterPro

Description

IPR002472 is a Palmitoyl protein thioesterase.

<p>This entry represents the palmitoyl protein thioesterase family. Its members include palmitoyl-protein thioesterase 1 and lysosomal thioesterase 2 (PPT1 and PPT2). PPT1 is responsible for the removal of a palmitate group from its substrate proteins, which may include presynaptic proteins like SNAP-25, cysteine string protein (CSP), dynamin, and synaptotagmin [[cite:PUB00072199]]. PPT2 removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA [[cite:PUB00029881]]. PPT1 and -2 perform non-redundant roles in lysosomal thioester catabolism [[cite:PUB00029881]].</p> <p>Mutations in the PPT1 gene cause infantile-onset neuronal ceroid lipofuscinosis (INCL), which is a severe pediatric neurodegenerative disorder [[cite:PUB00072200]].</p> <p>This entry also includes uncharacterised proteins from fungi and plants.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0098599
Molecular function Palmitoyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj2g3v1989240.1
– PREDICTED: palmitoyl-protein thioesterase 1-like [Glycine max] gi|356497117|ref|XP_003517409.1|
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SignalP-noTM_EUK SignalP 1 100.00