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IPR002478 is a PUA domain.
<p>The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found [[cite:PUB00003444]]. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis [[cite:PUB00036064], [cite:PUB00036065], [cite:PUB00097515]]. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA [[cite:PUB00097515], [cite:PUB00036063]]. This domain has an α/β architecture consisting of six β-strands and two short α-helices [[cite:PUB00097515]]. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases [[cite:PUB00036066]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 60S ribosome subunit biogenesis protein NIP7 homolog [Glycine max] gi|356562795|ref|XP_003549654.1| | 13 | ||
| – | PREDICTED: ribosomal RNA large subunit methyltransferase I-like [Glycine max] gi|356526415|ref|XP_003531813.1| | 23 | ||
| – | Malignant T cell-amplified sequence 1-A [Medicago truncatula] gi|357464025|ref|XP_003602294.1| | 13 | ||
| – | Ribosomal RNA small subunit methyltransferase B [Medicago truncatula] gi|357494215|ref|XP_003617396.1| | 20 | ||
| – | PREDICTED: eukaryotic translation initiation factor 2D-like [Glycine max] gi|356544210|ref|XP_003540547.1| | 18 | ||
| – | PREDICTED: H/ACA ribonucleoprotein complex subunit 4-like [Glycine max] gi|356525850|ref|XP_003531534.1| | 24 | ||
| – | PREDICTED: H/ACA ribonucleoprotein complex subunit 4-like [Glycine max] gi|356525850|ref|XP_003531534.1| | 24 | ||
| – | Ribosomal RNA small subunit methyltransferase B; TAIR: AT1G06560.1 NOL1/NOP2/sun family protein; Swiss-Prot: sp|Q7TS68|NSUN6_MOUSE Putative methyltransferase NSUN6; TrEMBL-Plants: tr|K7M4N7|K7M4N7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0043900 | 18 | ||
| – | Malignant T-cell-amplified sequence 1; TAIR: AT1G09150.1 pseudouridine synthase and archaeosine transglycosylase (PUA) domain-containing protein; Swiss-Prot: sp|Q2KIE4|MCTS1_BOVIN Malignant T-cell-amplified sequence 1; TrEMBL-Plants: tr|I3SF98|I3SF98_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0290800 | 17 | ||
| – | Malignant T-cell-amplified sequence 1 like; TAIR: AT1G09150.1 pseudouridine synthase and archaeosine transglycosylase (PUA) domain-containing protein; Swiss-Prot: sp|Q86KL4|MCTS1_DICDI Malignant T-cell-amplified sequence 1 homolog; TrEMBL-Plants: tr|I3SF98|I3SF98_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0290800 | 16 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|P0CL18|EIF2D_RABIT Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|I1LVH4|I1LVH4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055100 | 23 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|P0CL18|EIF2D_RABIT Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|I1LVH4|I1LVH4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0055100 | 23 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q5PPG7|EIF2D_RAT Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|A0A151RMC0|A0A151RMC0_CAJCA Ligatin; Found in the gene: LotjaGi3g1v0055100 | 12 | ||
| – | Eukaryotic translation initiation factor 2D; TAIR: AT1G71350.1 eukaryotic translation initiation factor SUI1 family protein; Swiss-Prot: sp|Q5RA63|EIF2D_PONAB Eukaryotic translation initiation factor 2D; TrEMBL-Plants: tr|G7JKR1|G7JKR1_MEDTR Eukaryotic translation initiation factor SUI1-like protein; Found in the gene: LotjaGi3g1v0055100 | 23 | ||
| – | Ribosomal RNA large subunit methyltransferase I; TAIR: AT1G54310.2 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|B4RRY8|RLMI_ALTMD Ribosomal RNA large subunit methyltransferase I; TrEMBL-Plants: tr|A0A151SMM6|A0A151SMM6_CAJCA Ribosomal RNA large subunit methyltransferase I; Found in the gene: LotjaGi3g1v0298500 | 17 | ||
| – | Ribosomal RNA large subunit methyltransferase I; TAIR: AT1G54310.2 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|B4RRY8|RLMI_ALTMD Ribosomal RNA large subunit methyltransferase I; TrEMBL-Plants: tr|A0A151SMM6|A0A151SMM6_CAJCA Ribosomal RNA large subunit methyltransferase I; Found in the gene: LotjaGi3g1v0298500 | 24 | ||
| – | Ribosomal RNA large subunit methyltransferase I; TAIR: AT1G54310.2 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|B4RRY8|RLMI_ALTMD Ribosomal RNA large subunit methyltransferase I; TrEMBL-Plants: tr|A0A151SMM6|A0A151SMM6_CAJCA Ribosomal RNA large subunit methyltransferase I; Found in the gene: LotjaGi3g1v0298500 | 24 | ||
| – | Ribosomal RNA large subunit methyltransferase I; TAIR: AT1G54310.2 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|B4RRY8|RLMI_ALTMD Ribosomal RNA large subunit methyltransferase I; TrEMBL-Plants: tr|A0A151SMM6|A0A151SMM6_CAJCA Ribosomal RNA large subunit methyltransferase I; Found in the gene: LotjaGi3g1v0298500 | 17 | ||
| – | TRNA pseudouridine synthase B; TAIR: AT3G57150.1 homologue of NAP57; Swiss-Prot: sp|Q9LD90|CBF5_ARATH H/ACA ribonucleoprotein complex subunit 4; TrEMBL-Plants: tr|V7BUX8|V7BUX8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0350500 | 26 | ||
| – | 60S ribosome subunit biogenesis protein NIP7 homolog; TAIR: AT4G15770.1 RNA binding protein; Swiss-Prot: sp|Q6DFH9|NIP7_XENLA 60S ribosome subunit biogenesis protein NIP7 homolog; TrEMBL-Plants: tr|V7CA90|V7CA90_PHAVU 60S ribosome subunit biogenesis protein NIP7 homolog; Found in the gene: LotjaGi6g1v0357900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF88802 | SUPERFAMILY | 1 | 5.00 |