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IPR002587 is a Myo-inositol-1-phosphate synthase.
<p>Myo-inositol 1-phosphate synthase ([ec:5.5.1.4]), also known as Inositol-3-phosphate synthase 1 (INO1), is a key enzyme in myo-inositol biosynthesis pathway that catalyses the conversion of glucose 6-phosphate to 1D-myo-inositol 3-phosphate in a NAD-dependent manner [[cite:PUB00106885], [cite:PUB00101379]]. The enzyme exists in a cytoplasmic form in a wide range of plants, animals, and fungi. It has also been detected in several bacteria and a chloroplast form is observed in alga and higher plants. Inositol phosphates play an important role in signal transduction.</p> <p>In Saccharomyces cerevisiae (Baker's yeast), the transcriptional regulation of the INO1 gene has been studied in detail [[cite:PUB00005654]] and its expression is sensitive to the availability of phospholipid precursors as well as growth phase. The regulation of the structural gene encoding 1L-myo-inositol-1-phosphate synthase has also been analysed at the transcriptional level in the aquatic angiosperm, Spirodela polyrrhiza (Giant duckweed) and the halophyte, Mesembryanthemum crystallinum (Common ice plant) [[cite:PUB00006393]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Inositol-3-phosphate synthase activity | Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. | ||
| Biological process | Inositol biosynthetic process | The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. | ||
| Biological process | Phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Myo-inositol-1-phosphate synthase [Glycine max] gi|84311237|gb|ABC55421.1| | 12 | ||
| – | Myo-inositol-1-phosphate synthase [Glycine max] gi|84311237|gb|ABC55421.1| | 12 | ||
| – | Myo-inositol-1-phosphate synthase; TAIR: AT2G22240.1 myo-inositol-1-phosphate synthase 2; Swiss-Prot: sp|Q9SSV4|INO1_NICPA Inositol-3-phosphate synthase; TrEMBL-Plants: tr|A0A0L9TKJ8|A0A0L9TKJ8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0399900 | 12 | ||
| – | Myo-inositol 1-phosphate synthase; TAIR: AT2G22240.1 myo-inositol-1-phosphate synthase 2; Swiss-Prot: sp|Q9SSV4|INO1_NICPA Inositol-3-phosphate synthase; TrEMBL-Plants: tr|A0A0L9TKJ8|A0A0L9TKJ8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0399900 | 12 | ||
| – | Myo-inositol-1-phosphate synthase; TAIR: AT2G22240.1 myo-inositol-1-phosphate synthase 2; Swiss-Prot: sp|Q9SSV4|INO1_NICPA Inositol-3-phosphate synthase; TrEMBL-Plants: tr|A0A151U8Z6|A0A151U8Z6_CAJCA Inositol-3-phosphate synthase; Found in the gene: LotjaGi6g1v0085700 | 12 | ||
| – | Myo-inositol-1-phosphate synthase; TAIR: AT2G22240.1 myo-inositol-1-phosphate synthase 2; Swiss-Prot: sp|Q9SSV4|INO1_NICPA Inositol-3-phosphate synthase; TrEMBL-Plants: tr|B6SBM2|B6SBM2_CICAR L-myo inositol-1 phosphate synthase 2; Found in the gene: LotjaGi6g1v0085700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55347 | SUPERFAMILY | 1 | 16.67 |