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IPR002637 is a RdgB/HAM1.
<p>This family contains a group of purine NTP pyrophosphatases, including dITP/XTP pyrophosphatase RdgB from E.coli and inosine triphosphate pyrophosphatase (ITPA, also known as HAM1) from Saccharomyces cerevisiae (Baker's yeast) ([swissprot:P47119]), as well as archaeal and Caenorhabditis elegans homologues. S. cerevisiae HAM1 was originally identified as a gene that protects against the mutagenic effects of the base analogue 6-N-hydroxylaminopurine (HAP) which can be a natural product of monooxygenase activity on adenine [[cite:PUB00005658], [cite:PUB00064772]]. Subsequent studies demonstrated that HAM1 detoxifies abnormal pyrimidine as well as purine nucleotides [[cite:PUB00064770]]. RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools [[cite:PUB00106860], [cite:PUB00046222], [cite:PUB00053239]].</p> <p>Similarly, a Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides such as XTP to XMP and ITP to IMP, but not the standard nucleotides, in the presence of Mg or Mn ions. The enzyme exists as a homodimer [[cite:PUB00023533]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Nucleoside triphosphate catabolic process | The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. | ||
| Molecular function | Nucleoside-triphosphate diphosphatase activity | Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: inosine triphosphate pyrophosphatase-like [Cicer arietinum] gi|502122466|ref|XP_004497758.1| | 8 | ||
| – | PREDICTED: inosine triphosphate pyrophosphatase-like [Cicer arietinum] gi|502122466|ref|XP_004497758.1| | 12 | ||
| – | Inosine triphosphate pyrophosphatase; TAIR: AT4G13720.2 Inosine triphosphate pyrophosphatase family protein; Swiss-Prot: sp|F6HS55|ITPA_VITVI Inosine triphosphate pyrophosphatase; TrEMBL-Plants: tr|I3SSJ2|I3SSJ2_LOTJA Inosine triphosphate pyrophosphatase; Found in the gene: LotjaGi6g1v0014000_LC | 10 | ||
| – | Non-canonical purine NTP pyrophosphatase; TAIR: AT4G13720.2 Inosine triphosphate pyrophosphatase family protein; Swiss-Prot: sp|F6HS55|ITPA_VITVI Inosine triphosphate pyrophosphatase; TrEMBL-Plants: tr|I3SSJ2|I3SSJ2_LOTJA Inosine triphosphate pyrophosphatase; Found in the gene: LotjaGi6g1v0014000_LC | 7 | ||
| – | Non-canonical purine NTP pyrophosphatase; TAIR: AT4G13720.2 Inosine triphosphate pyrophosphatase family protein; Swiss-Prot: sp|F6HS55|ITPA_VITVI Inosine triphosphate pyrophosphatase; TrEMBL-Plants: tr|I3SSJ2|I3SSJ2_LOTJA Inosine triphosphate pyrophosphatase; Found in the gene: LotjaGi6g1v0014000_LC | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00515 | CDD | 1 | 20.00 |