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IPR002813 is a Arginine biosynthesis protein ArgJ.
<p>ArgJ (also known as Ornithine acetyltransferase/OAT) is a bifunctional protein that catalyses the first [ec:2.3.1.35] and fifth steps [ec:2.3.1.1] in arginine biosynthesis [[cite:PUB00005708]], coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in the arginine biosynthetic pathway. The structure has been determined for glutamate N-acetyltransferase 2 (ornithine acetyltransferase; [ec:2.3.1.35]), an ArgJ-like protein from Streptomyces clavuligerus [[cite:PUB00037999]].</p> <p>Members of this family may experience feedback inhibition by L-arginine. The active enzyme is a heterotetramer of two alpha and two beta chains, where the alpha and beta chains are the result of autocatalytic cleavage. OATs found in the clavulanic acid biosynthesis gene cluster catalyze the fifth step only, and may utilize acetyl acceptors other than glutamate [[cite:PUB00079801], [cite:PUB00037999], [cite:PUB00014499], [cite:PUB00005708], [cite:PUB00079802], [cite:PUB00079803]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glutamate N-acetyltransferase activity | Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. | ||
| Biological process | Arginine biosynthetic process | The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: arginine biosynthesis bifunctional protein ArgJ, chloroplastic-like [Glycine max] gi|356548150|ref|XP_003542466.1| | 11 | ||
| – | PREDICTED: arginine biosynthesis bifunctional protein ArgJ, chloroplastic-like [Cicer arietinum] gi|502114663|ref|XP_004495013.1| | 8 | ||
| – | PREDICTED: arginine biosynthesis bifunctional protein ArgJ, chloroplastic-like [Glycine max] gi|356548150|ref|XP_003542466.1| | 8 | ||
| – | Arginine biosynthesis bifunctional protein ArgJ; TAIR: AT2G37500.1 arginine biosynthesis protein ArgJ family; Swiss-Prot: sp|B9SZB6|ARGJ_RICCO Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; TrEMBL-Plants: tr|I1LYU9|I1LYU9_SOYBN Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; Found in the gene: LotjaGi5g1v0068900 | 13 | ||
| – | Arginine biosynthesis bifunctional protein ArgJ; TAIR: AT2G37500.1 arginine biosynthesis protein ArgJ family; Swiss-Prot: sp|B9SZB6|ARGJ_RICCO Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; TrEMBL-Plants: tr|A0A072VLB2|A0A072VLB2_MEDTR Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; Found in the gene: LotjaGi5g1v0068900 | 13 | ||
| – | Arginine biosynthesis bifunctional protein ArgJ; TAIR: AT2G37500.1 arginine biosynthesis protein ArgJ family; Swiss-Prot: sp|B9SZB6|ARGJ_RICCO Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; TrEMBL-Plants: tr|A0A072VLB2|A0A072VLB2_MEDTR Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; Found in the gene: LotjaGi5g1v0068900 | 13 | ||
| – | Arginine biosynthesis bifunctional protein ArgJ; TAIR: AT2G37500.1 arginine biosynthesis protein ArgJ family; Swiss-Prot: sp|B9SZB6|ARGJ_RICCO Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; TrEMBL-Plants: tr|I1LYU9|I1LYU9_SOYBN Arginine biosynthesis bifunctional protein ArgJ, chloroplastic; Found in the gene: LotjaGi5g1v0068900 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02152 | CDD | 1 | 14.29 |