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IPR003099 is a Prephenate dehydrogenase.
<p>This entry represents prephenate dehydrogenase (PDHG) [ec:1.3.1.12], an enzyme involved in tyrosine biosynthesis [[cite:PUB00061316]] and related proteins.</p> <p>Three enzymes catalyse the conversion of chorismate to hydroxyphenylpyruvate or pyruvate in the aromatic amino acid biosynthesis pathway. In this pathway, chorismate is a branch point intermediate that is converted to tryptophan, phenylalanine (Phe), and tyrosine (Tyr). In bacteria the enzymes, chorismate mutase (CM), prephenate dehydratase (PDT), and prephenate dehydrogenase (PDHG) are either present as distinct proteins or fusions combining two activities [[cite:PUB00066096]]. In the archaea Archaeoglobus fulgidus a single protein (AroQ) contains all three enzymatic domains [[cite:PUB00070219]].</p> <p>This entry also matches 3-phosphoshikimate 1-carboxyvinyltransferase [ec:2.5.1.19].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Prephenate dehydrogenase (NADP+) activity | Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH. | ||
| Biological process | Tyrosine biosynthetic process | The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. | ||
| Molecular function | Prephenate dehydrogenase (NAD+) activity | Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Arogenate dehydrogenase [Medicago truncatula] gi|357478359|ref|XP_003609465.1| | 11 | ||
| – | Arogenate dehydrogenase [Medicago truncatula] gi|357461443|ref|XP_003601003.1| | 11 | ||
| – | Arogenate dehydrogenase; TAIR: AT5G34930.3 arogenate dehydrogenase; Swiss-Prot: sp|Q944B6|TYRA1_ARATH Arogenate dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7JGK2|G7JGK2_MEDTR Prephenate dehydrogenase; Found in the gene: LotjaGi4g1v0279700 | 11 | ||
| – | Arogenate dehydrogenase; TAIR: AT5G34930.1 arogenate dehydrogenase; Swiss-Prot: sp|Q944B6|TYRA1_ARATH Arogenate dehydrogenase 1, chloroplastic; TrEMBL-Plants: tr|G7J2E9|G7J2E9_MEDTR Prephenate dehydrogenase; Found in the gene: LotjaGi6g1v0081800 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51735 | SUPERFAMILY | 1 | 25.00 |