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IPR003195 is a Transcription initiation factor IID, subunit 13.
<p>This family includes the Spt3 yeast transcription factors and the 18kDa subunit from human transcription initiation factor IID, known as TAF13 or TAFII18. Determination of the crystal structure reveals an atypical histone fold [[cite:PUB00006419]].</p> <p>TBP-associated factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming the transcription factor IID (TFIID) complex. TAF13 interacts with TAF11 and makes a histone-like heterodimer similar to H3/H4-like proteins. The dimer may be structurally and functionally similar to the spt3 protein within the SAGA histone acetyltransferase complex [[cite:PUB00006419]].</p> <p>TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the pre-initiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers. The minimal HFD contains three α-helices linked by two loops and are found in core histones, TAFs and many other transcription factors. TFIID has a histone octamer-like substructure.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription initiation factor TFIID subunit 13-like [Glycine max] gi|356534862|ref|XP_003535970.1| | 8 | ||
| – | Transcription initiation factor TFIID subunit 13; TAIR: AT1G02680.1 TBP-associated factor 13; Swiss-Prot: sp|Q6NQH4|TAF13_ARATH Transcription initiation factor TFIID subunit 13; TrEMBL-Plants: tr|I3T0K3|I3T0K3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0246600 | 9 | ||
| – | Transcription initiation factor TFIID subunit 13; TAIR: AT1G02680.1 TBP-associated factor 13; Swiss-Prot: sp|Q6NQH4|TAF13_ARATH Transcription initiation factor TFIID subunit 13; TrEMBL-Plants: tr|I3T0K3|I3T0K3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0246600 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |