Description

IPR003299 is a Flagellar calcium-binding protein calflagin.

<p>The protozoan parasite that causes Chagas' disease, Trypanosoma cruzi, contains a 24kDa protein that is recognised by antisera from both humans and experimental animals infected with this organism. Near its C terminus are two regions that have sequence similarity with E-F hand Ca²⁺-binding proteins [[cite:PUB00008082]]. Indeed, the native trypanosome protein exhibits low Ca²⁺-binding capacity and high Ca²⁺-binding affinity, consistent with binding via E-F hand structures. Immunofluorescence assays have suggested that the protein is localised to the trypanosome's flagellum. This observation, coupled with the protein's Ca²⁺-binding properties, suggests that it may participate in molecular processes associated with the high motility of the parasite [[cite:PUB00008082]].<p>A set of similar 24kDa proteins, termed calflagins, are contained within the flagellum of Trypanosoma brucei. These contain three EF-hand Ca²⁺- binding domains and one degenerate EF-hand motif [[cite:PUB00008083]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: