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IPR003721 is a Pantoate-beta-alanine ligase.
<p>D-Pantothenate is synthesized via four enzymes from ketoisovalerate, which is an intermediate of branched-chain amino acid synthesis [[cite:PUB00008210]]. Pantoate-beta-alanine ligase, also know as pantothenate synthase, (PanC; [ec:6.3.2.1]) catalyzes the formation of pantothenate from pantoate and alanine in the pantothenate biosynthesis pathway [[cite:PUB00008211]].</p> <p>PanC belongs to a large superfamily of nucleotidyltransferases that includes ATP sulfurylase (ATPS), phosphopantetheine adenylyltransferase (PPAT), and the amino-acyl tRNA synthetases. The enzymes of this family are structurally similar and share a dinucleotide-binding domain [[cite:PUB00079882], [cite:PUB00079800], [cite:PUB00019988], [cite:PUB00079883], [cite:PUB00079884]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Pantoate-beta-alanine ligase activity | Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. | ||
| Biological process | Pantothenate biosynthetic process | The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Pantoate--beta-alanine ligase; AltName: Full=Pantoate-activating enzyme; AltName: Full=Pantothenate synthetase; Flags: Precursorgi|2292921|emb|CAA71302.1| pantoate--beta-alanine ligase [Lotus japonicus] gi|14285652|sp|O24035.3|PANC_LOTJA | 17 | ||
| – | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00560 | CDD | 1 | 50.00 |