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IPR003835 is a Glycosyl transferase, family 19.
<p>The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([ec:2.4.1.-]) and related proteins into distinct sequence based families has been described [[cite:PUB00009409]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.</p> <p>These enzymes belong to the glycosyltransferase family 19 [cazy:GT19]. Lipid-A-disaccharide synthetase [ec:2.4.1.182] is involved with acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase [ec:2.3.1.129] and tetraacyldisaccharide 4'-kinase [ec:2.7.1.130] in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli and other bacteria. These enzymes catalyse the first disaccharide step in the synthesis of lipid-A-disaccharide.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Lipid-A-disaccharide synthase activity | Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP. | ||
| Biological process | Lipid A biosynthetic process | The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable lipid-A-disaccharide synthase, mitochondrial-like [Cicer arietinum] gi|502156214|ref|XP_004510363.1| | 4 | ||
| – | PREDICTED: lipid-A-disaccharide synthase-like [Glycine max] gi|356499725|ref|XP_003518687.1| | 5 | ||
| – | PREDICTED: probable lipid-A-disaccharide synthase, mitochondrial-like [Cicer arietinum] gi|502156214|ref|XP_004510363.1| | 7 | ||
| – | Lipid-A-disaccharide synthase; TAIR: AT2G04560.1 transferases, transferring glycosyl groups; Swiss-Prot: sp|F4IF99|LPXB_ARATH Probable lipid-A-disaccharide synthase, mitochondrial; TrEMBL-Plants: tr|V7C7I5|V7C7I5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0085500 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00215 | TIGRFAM | 1 | 25.00 |