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IPR004139 is a Glycosyl transferase, family 13.
<p>The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([ec:2.4.1.-]) and related proteins into distinct sequence based families has been described [[cite:PUB00009409]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.</p> <p>Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, GLCNAC-T I) [ec:2.4.1.101] transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus, and is probably distributed in all tissues [[cite:PUB00007376]]. Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNTI, GNT-I.2) participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins [[cite:PUB00089708], [cite:PUB00090058], [cite:PUB00092645]]. These proteins are members of the glycosyl transferase family 13 ([cazy:GH13])</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. | ||
| Molecular function | Acetylglucosaminyltransferase activity | Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase-like isoform 1 [Glycine max] gi|356510509|ref|XP_003523980.1| | 14 | ||
| – | PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase-like [Glycine max] gi|356516122|ref|XP_003526745.1| | 8 | ||
| – | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; TAIR: AT4G38240.1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; Swiss-Prot: sp|Q9XGM8|MGAT1_ARATH Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; TrEMBL-Plants: tr|I3S0S7|I3S0S7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0555400 | 15 | ||
| – | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; TAIR: AT4G38240.1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; Swiss-Prot: sp|Q9XGM8|MGAT1_ARATH Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; TrEMBL-Plants: tr|I3S0S7|I3S0S7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0555400 | 15 | ||
| – | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; TAIR: AT4G38240.1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; Swiss-Prot: sp|Q9XGM8|MGAT1_ARATH Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; TrEMBL-Plants: tr|I3S0S7|I3S0S7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0555400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02514 | CDD | 1 | 20.00 |