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IPR004177 is a DDHD domain.
<p>The Nir/rdgB (N-terminal domain-interacting receptor/Drosophila retinal degeneration B proteins) family has been identified in a variety of eukaryotic organisms, ranging from worms to mammals. Members of this family are implicated in regulation of lipid trafficking, metabolism, and signaling. The Nir/rdgB proteins contain a 180 amino-acids-long conserved region in the central part of the protein. This domain contains four conserved residues, DDHD, which may form a metal-binding site. This domain is named DDHD after these four residues. This pattern of conservation of metal-binding residues is often seen in phosphoesterase domains [[cite:PUB00018498]].</p> <p>The DDHD domain is found in the central part of Nir/rdgB proteins, as well as the C-terminal part of the phosphatidic acid-preferring phospholipase A1. The DDHD domain function is not currently known but it may be implicated in phospholipid metabolism, membrane turnover, or intracellular trafficking [[cite:PUB00018498]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phospholipase DDHD1-like [Cicer arietinum] gi|502146261|ref|XP_004506374.1| | 6 | ||
| – | PREDICTED: phospholipase DDHD1-like [Glycine max] gi|356529907|ref|XP_003533528.1| | 8 | ||
| – | PREDICTED: phospholipase DDHD1-like [Glycine max] gi|356529907|ref|XP_003533528.1| | 8 | ||
| – | Shoot gravitropism 2 (SGR2) protein; TAIR: AT1G31480.1 shoot gravitropism 2 (SGR2); Swiss-Prot: sp|Q8W5R2|SHGR2_ARATH Phospholipase SGR2; TrEMBL-Plants: tr|K7LFN8|K7LFN8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0555800 | 10 | ||
| – | Shoot gravitropism 2 (SGR2) protein; TAIR: AT1G31480.1 shoot gravitropism 2 (SGR2); Swiss-Prot: sp|Q8W5R2|SHGR2_ARATH Phospholipase SGR2; TrEMBL-Plants: tr|K7LFN8|K7LFN8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0555800 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |