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IPR004843 is a Calcineurin-like, phosphoesterase domain.
This domain is found in a diverse range of phosphoesterases [[PMID:9685491]], including bis(5'-nucleosyl)-tetraphosphatase (apaH), nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases, as well as nucleases such as bacterial SbcD or archaeal/yeast Mre11. The most conserved regions in the Calcineurin-like domain center around the metal-chelating residues. The structure typically comprises two sandwiched β-sheets flanked by α-helical segments, with the binuclear metal center located at the interface between two symmetrical halves of the molecule. This domain arrangement allows PAPs to perform their characteristic phosphatase activity under acidic conditions [[PMID:9685491]].
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. |