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IPR004911 is a Gamma interferon inducible lysosomal thiol reductase GILT.
<p>In humans, GILT (gamma-interferon-inducible lysosomal thiol reductase) functions in MHC class II-restricted antigen processing and MHC class I-restricted cross-presentation by reducing disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation [[cite:PUB00083909], [cite:PUB00083906]]. Several other functions of GILT have also been found, for instance, GILT can act as a host factor for Listeria monocytogenes infection and is involved in the maintenance of cellular glutathione (GSH) levels [[cite:PUB00083909]].</p> <p>GILT is characterised by a CXXC motif in the active site and an enzymatic mechanism in which the pair of active site cysteine residues cooperate to reduce substrate disulfide bonds [[cite:PUB00083909]]. The GIL homologues from Drosophila melanogaster may play a role in the innate immune response upon bacterial challenge [[cite:PUB00083905]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like [Cicer arietinum] gi|502129444|ref|XP_004500307.1| | 13 | ||
| – | Gamma-interferon-inducible lysosomal thiol reductase [Medicago truncatula] gi|357458115|ref|XP_003599338.1| | 13 | ||
| – | Gamma-interferon-inducible lysosomal thiol reductase [Medicago truncatula] gi|357468575|ref|XP_003604572.1| | 10 | ||
| – | PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like [Glycine max] gi|356496241|ref|XP_003516977.1| | 14 | ||
| – | Gamma interferon inducible lysosomal thiol reductase; TAIR: AT1G07080.1 Thioredoxin superfamily protein; Swiss-Prot: sp|Q9ESY9|GILT_MOUSE Gamma-interferon-inducible lysosomal thiol reductase; TrEMBL-Plants: tr|I3SDV9|I3SDV9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0197200 | 10 | ||
| – | Gamma-interferon-inducible lysosomal thiol reductase; TAIR: AT5G01580.1 gamma interferon responsive lysosomal thiol (GILT) reductase family protein; Swiss-Prot: sp|Q499T2|GILT_RAT Gamma-interferon-inducible lysosomal thiol reductase; TrEMBL-Plants: tr|I1JL84|I1JL84_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0197400 | 14 | ||
| – | Gamma interferon inducible lysosomal thiol reductase; TAIR: AT1G07080.1 Thioredoxin superfamily protein; Swiss-Prot: sp|A6QPN6|GILT_BOVIN Gamma-interferon-inducible lysosomal thiol reductase; TrEMBL-Plants: tr|A0A1J7G410|A0A1J7G410_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0117400 | 13 | ||
| – | Gamma interferon inducible lysosomal thiol reductase; TAIR: AT1G07080.1 Thioredoxin superfamily protein; Swiss-Prot: sp|A6QPN6|GILT_BOVIN Gamma-interferon-inducible lysosomal thiol reductase; TrEMBL-Plants: tr|A0A1J7G410|A0A1J7G410_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0117500 | 13 | ||
| – | Gamma interferon inducible lysosomal thiol reductase; TAIR: AT1G07080.1 Thioredoxin superfamily protein; Swiss-Prot: sp|A6QPN6|GILT_BOVIN Gamma-interferon-inducible lysosomal thiol reductase; TrEMBL-Plants: tr|G7J0S1|G7J0S1_MEDTR Gamma interferon inducible lysosomal thiol reductase; Found in the gene: LotjaGi6g1v0117600 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TMhelix | TMHMM | 1 | 11.11 |