Description

IPR004939 is a APC10/DOC domain.

<p>The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [[cite:PUB00059221]].</p> <p>One of the subunits of the APC that is required for ubiquitination activity is APC10, a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see [prositedoc:PDOC00449]), cullin (see [prositedoc:PDOC00967]) or HECT (see [prositedoc:PDOC50237]) domains [[cite:PUB00019152], [cite:PUB00026391], [cite:PUB00014924]].</p> <p>The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold [[cite:PUB00026391], [cite:PUB00014924]].</p> <p>Proteins known to contain a DOC domain include:</p> <ul> <li>Eucaryotic Doc1/Apc10.</li> <li>Mammalian protein associated with the transcription factor Myc (PAM).</li> <li>Mouse runty-jerky-sterile (RJS) protein.</li> <li>Human HERC2, the ortholog of RJS.</li> </ul>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: