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IPR004948

Source: InterPro

Description

IPR004948 is a Nucleoside-triphosphatase, THEP1 type.

<p>This entry represents a family of nucleoside-triphosphatases which have activity towards ATP, GTP, CTP, TTP and UTP and may hydrolyse nucleoside diphosphates with lower efficiency [[cite:PUB00041591]]. It includes proteins from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [[cite:PUB00055956]]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [[cite:PUB00032635]]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [[cite:PUB00041591]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0098519
Molecular function Nucleotide phosphatase activity, acting on free nucleotides Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj2g3v1613110.1
– PREDICTED: cancer-related nucleoside-triphosphatase homolog isoform X1 [Cicer arietinum] gi|502161741|ref|XP_004512269.1|
Domains
6
Lj2g3v1613110.2
– PREDICTED: cancer-related nucleoside-triphosphatase homolog isoform X1 [Cicer arietinum] gi|502161741|ref|XP_004512269.1|
Domains
9
LotjaGi2g1v0354900.1
– Nucleoside-triphosphatase THEP1; TAIR: AT5G66005.3 Expressed protein; Swiss-Prot: sp|Q9BSD7|NTPCR_HUMAN Cancer-related nucleoside-triphosphatase; TrEMBL-Plants: tr|A0A1J7GSZ1|A0A1J7GSZ1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0354900
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd03114 CDD 1 33.33