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IPR005552

Source: InterPro

Description

IPR005552 is a Scramblase.

This entry represents phospholipid scramblases. These are plasma membrane proteins, which are conserved from worms to humans. They have been originally identified based on their ability to accelerate the transbilayer movement of phospholipids in a calcium-dependent manner [[cite:PUB00103899]]. <p>Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca<sup>2+</sup>-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury [[cite:PUB00008442]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0017121
Biological process Phospholipid scrambling The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE).
Subterm of
GO:0017128
Molecular function Phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj3g3v3640170.1
– PREDICTED: altered inheritance rate of mitochondria protein 25-like [Glycine max] gi|356543498|ref|XP_003540197.1|
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00