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IPR005756

Description

IPR005756 is a Large ribosomal subunit protein uL24, eukaryotic/archaeal.

<p>Ribosomal protein uL24 is one of the proteins from the large ribosomal subunit. In their mature form, these proteins have 103 to 150 amino-acid residues. The eukaryotic uL24 is a conserved protein that shares significant sequence and structure similarity with archaeal and eubacterial uL24. This entry represents the archaeal and eukaryotic uL24. The eukaryotic protein was previously known as L26.</p> <p>Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [[cite:PUB00007068], [cite:PUB00007069]]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits.</p> <p>Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [[cite:PUB00007069], [cite:PUB00007070]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.
Biological process Translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
Cellular component Large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
PREDICTED: 60S ribosomal protein L26-1-like [Glycine max] gi|356555056|ref|XP_003545855.1| 15
Translation protein SH3-like family protein [Theobroma cacao] gi|508717912|gb|EOY09809.1| 17
60S ribosomal protein L26; TAIR: AT3G49910.1 Translation protein SH3-like family protein; Swiss-Prot: sp|P51414|RL261_ARATH 60S ribosomal protein L26-1; TrEMBL-Plants: tr|A0A151T7I3|A0A151T7I3_CAJCA 60S ribosomal protein L26-1; Found in the gene: LotjaGi2g1v0246000_LC 14
Ribosomal protein L24; TAIR: AT3G49910.1 Translation protein SH3-like family protein; Swiss-Prot: sp|P51414|RL261_ARATH 60S ribosomal protein L26-1; TrEMBL-Plants: tr|I3SSN9|I3SSN9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0409300 19
60S ribosomal protein L26, putative; TAIR: AT3G49910.1 Translation protein SH3-like family protein; Swiss-Prot: sp|P51414|RL261_ARATH 60S ribosomal protein L26-1; TrEMBL-Plants: tr|A0A151T7I3|A0A151T7I3_CAJCA 60S ribosomal protein L26-1; Found in the gene: LotjaGi6g1v0337500 19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 20.00