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IPR005959

Source: InterPro

Description

IPR005959 is a Fumarylacetoacetase.

<p>Fumarylacetoacetase ([ec:3.7.1.2]; also known as fumarylacetoacetate hydrolase or FAH) catalyses the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield fumarate and acetoacetate as the final step in phenylalanine and tyrosine degradation [[cite:PUB00025833], [cite:PUB00099624]]. This is an essential metabolic function in humans, the lack of FAH causing type I tyrosinemia, which is associated with liver and kidney abnormalities and neurological disorders [[cite:PUB00035625], [cite:PUB00002007]]. The enzyme mechanism involves a catalytic metal ion, a Glu/His catalytic dyad, and a charged oxyanion hole [[cite:PUB00022554]]. FAH folds into two domains: an N-terminal domain SH3-like β-barrel, and a C-terminal with an unusual fold consisting of three layers of β-sheet structures [[cite:PUB00022554]].</p> <p>In Aspergillus fumigatus, this enzyme is part of the L-tyrosine degradation gene cluster that mediates the biosynthesis of the brownish pigment pyomelanin as an alternative melanin [[cite:PUB00099555], [cite:PUB00099556]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004334
Molecular function Fumarylacetoacetase activity Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).
Subterm of
GO:0009072
Biological process Aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj6g3v1766600.1
– PREDICTED: fumarylacetoacetase-like [Cicer arietinum] gi|502079297|ref|XP_004486216.1|
Domains
12
LotjaGi6g1v0287200.1
– Fumarylacetoacetase; TAIR: AT1G12050.1 fumarylacetoacetase; Swiss-Prot: sp|A5PKH3|FAAA_BOVIN Fumarylacetoacetase; TrEMBL-Plants: tr|I3SQB1|I3SQB1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0287200
Domains
14
LotjaGi6g1v0287200.2
– Fumarylacetoacetase; TAIR: AT1G12050.1 fumarylacetoacetase; Swiss-Prot: sp|A5PKH3|FAAA_BOVIN Fumarylacetoacetase; TrEMBL-Plants: tr|I3SQB1|I3SQB1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0287200
Domains
14
LotjaGi6g1v0287200.3
– Fumarylacetoacetase; TAIR: AT1G12050.1 fumarylacetoacetase; Swiss-Prot: sp|A5PKH3|FAAA_BOVIN Fumarylacetoacetase; TrEMBL-Plants: tr|I3SQB1|I3SQB1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0287200
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01266 TIGRFAM 1 25.00