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IPR006009 is a N-acetylglucosaminyltransferase, MurG.
<p>The murG gene of Escherichia coli encodes the N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, responsible for the final step in the formation of the lipid-linked disaccharide-pentapeptide subunit of peptidoglycan [[cite:PUB00080974]]. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. The enzyme is peripherally associated with the inner face of the cytoplasmic membrane. Therefore, the peptidoglycan subunit is completely assembled before it traverses the cytoplasmic membrane [[cite:PUB00033163]].</p> <p>MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N-and C-terminal domains, each containing a typical Rossmann fold [[cite:PUB00024731]]. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic centre and permits a high degree of flexibility.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase-like [Glycine max] gi|356511279|ref|XP_003524354.1| | 16 | ||
| – | UDP-N-acetylglucosamine--N-acetylmuramyl-(Pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; TAIR: AT1G73740.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|B3QWT7|MURG_CHLT3 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; TrEMBL-Plants: tr|K7KRG7|K7KRG7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0460300 | 16 | ||
| – | UDP-N-acetylglucosamine--N-acetylmuramyl-(Pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; TAIR: AT1G73740.1 UDP-Glycosyltransferase superfamily protein; Swiss-Prot: sp|B3QWT7|MURG_CHLT3 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; TrEMBL-Plants: tr|K7KRG7|K7KRG7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0460300 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03785 | CDD | 1 | 33.33 |