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IPR006218

Source: InterPro

Description

IPR006218 is a DAHP synthetase I/KDSA.

<p>Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms (see [interpro:IPR002480]) [[cite:PUB00006352]]. <p>The first step in the common pathway leading to the biosynthesis of aromatic compounds is the stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). This reaction is catalyzed by DAHP synthase, a metal-activated enzyme, which in microorganisms is the target for negative-feedback regulation by pathway intermediates or by end products. In Escherichia coli there are three DAHP synthetase isoforms, each specifically inhibited by one of the three aromatic amino acids. The crystal structure of the phenylalanine-regulated form of DAHP synthetase shows the fold as is a (β/α)8 barrel with several additional β strands and α helices [[cite:PUB00006452]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0009058
Biological process Biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v2898480.1
– 2-dehydro-3-deoxyphosphooctonate aldolase [Medicago truncatula] gi|357507985|ref|XP_003624281.1|
Domains
10
LotjaGi1g1v0492600.1
– 2-dehydro-3-deoxyphosphooctonate aldolase; TAIR: AT1G79500.1 Aldolase-type TIM barrel family protein; Swiss-Prot: sp|O50044|KDSA_PEA 2-dehydro-3-deoxyphosphooctonate aldolase; TrEMBL-Plants: tr|I3ST49|I3ST49_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0492600
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01362 TIGRFAM 1 50.00