Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR006368

Source: InterPro

Description

IPR006368 is a GDP-mannose 4,6-dehydratase.

<p>This family represent GDP-mannose 4,6-dehydratase, also known as GDP-D-mannose dehydratase. This enzyme converts GDP-mannose to GDP-4-dehydro-6-deoxy-D-mannose, the first of three steps for the conversion of GDP-mannose to GDP-fucose in animals, plants, and bacteria. In bacteria, GDP-L-fucose acts as a precursor of surface antigens such as the extracellular polysaccharide colanic acid of Escherichia coli. Excluded from this family are members of the clade that are poorly related because of highly dervied (phylogenetically long-branch) sequences, e.g. Aneurinibacillus thermoaerophilus Gmd, described as a bifunctional GDP-mannose 4,6-dehydratase/GDP-6-deoxy-D-lyxo-4-hexulose reductase [[cite:PUB00009601]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008446
Molecular function GDP-mannose 4,6-dehydratase activity Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O.
Subterm of
GO:0019673
Biological process GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj2g3v1705440.1
–
Domains
12
LotjaGi2g1v0382700.1
– GDP-mannose 4,6 dehydratase-like protein; TAIR: AT3G51160.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|P93031|GMD2_ARATH GDP-mannose 4,6 dehydratase 2; TrEMBL-Plants: tr|V7CIA4|V7CIA4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0382700
Domains
13
LotjaGi2g1v0382700.2
– GDP-mannose 4,6 dehydratase-like protein; TAIR: AT3G51160.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|P93031|GMD2_ARATH GDP-mannose 4,6 dehydratase 2; TrEMBL-Plants: tr|V7CIA4|V7CIA4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0382700
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33