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IPR006405 is a Nicotinate phosphoribosyltransferase pncB-type.
<p>A deep split separates two related families of proteins, one of which includes experimentally characterised examples of nicotinate phosphoribosyltransferase ([interpro:IPR006406]), the first enzyme of NAD salvage biosynthesis. This entry represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are from Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cut-offs.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Nicotinate phosphoribosyltransferase activity | Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. | ||
| Biological process | NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nicotinate phosphoribosyltransferase-like [Cicer arietinum] gi|502152869|ref|XP_004509133.1| | 13 | ||
| – | Nicotinate phosphoribosyltransferase; TAIR: AT2G23420.1 nicotinate phosphoribosyltransferase 2; Swiss-Prot: sp|Q84WV8|NPRT2_ARATH Nicotinate phosphoribosyltransferase 2; TrEMBL-Plants: tr|I1K246|I1K246_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0103900 | 18 | ||
| – | Nicotinate phosphoribosyltransferase-like protein; TAIR: AT2G23420.1 nicotinate phosphoribosyltransferase 2; Swiss-Prot: sp|Q84WV8|NPRT2_ARATH Nicotinate phosphoribosyltransferase 2; TrEMBL-Plants: tr|A0A1J7HTG5|A0A1J7HTG5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0103900 | 17 | ||
| – | Nicotinate phosphoribosyltransferase-like protein; TAIR: AT2G23420.1 nicotinate phosphoribosyltransferase 2; Swiss-Prot: sp|Q84WV8|NPRT2_ARATH Nicotinate phosphoribosyltransferase 2; TrEMBL-Plants: tr|A0A1J7HTG5|A0A1J7HTG5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0103900 | 17 | ||
| – | Nicotinate phosphoribosyltransferase; TAIR: AT2G23420.1 nicotinate phosphoribosyltransferase 2; Swiss-Prot: sp|Q84WV8|NPRT2_ARATH Nicotinate phosphoribosyltransferase 2; TrEMBL-Plants: tr|A0A1J7HTG5|A0A1J7HTG5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0103900 | 19 | ||
| – | Nicotinate phosphoribosyltransferase-like protein; TAIR: AT2G23420.1 nicotinate phosphoribosyltransferase 2; Swiss-Prot: sp|Q84WV8|NPRT2_ARATH Nicotinate phosphoribosyltransferase 2; TrEMBL-Plants: tr|A0A1J7HTG5|A0A1J7HTG5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0103900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01570 | CDD | 1 | 16.67 |