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IPR006773 is a Proteasomal ubiquitin receptor Rpn13/ADRM1.
<p>This entry includes Rpn13 from budding yeasts and its homologue, ADRM1 from animals.</p> <p>Rpn13 is a subunit and an ubiquitin receptor of the 19S regulatory particle of the 26S proteasome lid. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain [[cite:PUB00053442]]. The domain forms two contiguous anti-parallel β-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold [[cite:PUB00049233], [cite:PUB00054318]]. Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37 [[cite:PUB00049233]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: proteasomal ubiquitin receptor ADRM1-like [Glycine max] gi|356513237|ref|XP_003525320.1| | 7 | ||
| – | Regulatory particle non-ATPase 13; TAIR: AT2G26590.1 regulatory particle non-ATPase 13; Swiss-Prot: sp|O48726|RPN13_ARATH 26S proteasome regulatory subunit RPN13; TrEMBL-Plants: tr|I3SGU9|I3SGU9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0221000_LC | 14 | ||
| – | Regulatory particle non-ATPase 13; TAIR: AT2G26590.1 regulatory particle non-ATPase 13; Swiss-Prot: sp|O48726|RPN13_ARATH 26S proteasome regulatory subunit RPN13; TrEMBL-Plants: tr|I3SGU9|I3SGU9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0439200 | 11 | ||
| – | Regulatory particle non-ATPase 13; TAIR: AT2G26590.1 regulatory particle non-ATPase 13; Swiss-Prot: sp|O48726|RPN13_ARATH 26S proteasome regulatory subunit RPN13; TrEMBL-Plants: tr|I3SGU9|I3SGU9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0439200 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |