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IPR007072

Source: InterPro

Description

IPR007072 is a Rhamnosyl O-methyltransferase.

<p>This entry contains Rhamnosyl O-methyltransferase which catalyses the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD) [[cite:PUB00053670]]. Members of this family are about 220 amino acids long. It also includes the CmcI protein [swissprot:O85726], which was previously thought to represent the cephalosporin-7--hydroxylase [[cite:PUB00008735]], however, it is apparently a methyltransferase that works with hydroxylase CmcJ, and its most likely function is to catalyse the transfer of a methyl group from SAM to the 7alpha-hydroxy cephalosporin in the second catalytic reaction of cephamycin formation. Studies using recombinant proteins purified from E. coli suggest that the complex, but not the separate proteins, exhibits a strong interaction with SAM and cephalosporin C [[cite:PUB00039678]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of
GO:0008610
Biological process Lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj0g3v0220469.1
– S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Theobroma cacao] gi|508703717|gb|EOX95613.1|
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 100.00