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IPR007518 is a MINDY deubiquitinase.
<p>This entry represents a group of deubiquitinating (DUB) enzymes known as the MINDY family (MIU-containing novel DUB). Ubiquitin (Ub) is released one molecule at a time from the distal end of proteins with Lys48-linked polyubiquitin chains. Long polyubiquitin chains are preferred. The catalytic Cys and His residues have been identified by site-directed mutagenesis, as has the Gln that participates in formation of the oxyanion hole during catalysis. Despite the structural similarity to papain-like cysteine peptidases, a residue corresponding to the Asn that orientates the imidazolium ring of the catalytic His has not been identified. Members of the MINDY family of DUBs contain an MIU (motif interacting with Ub) motif, which is a helical motif that binds mono-Ub [[cite:PUB00081935]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Thiol-dependent ubiquitin-specific protease activity | Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. | ||
| Molecular function | Lys48-specific deubiquitinase activity | Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein FAM63B-like [Cicer arietinum] gi|502160053|ref|XP_004511617.1| | 5 | ||
| – | DNA-directed RNA polymerase III subunit RPC5; TAIR: AT5G49530.1 SIN-like family protein; Swiss-Prot: sp|Q76LS9|FA63A_MOUSE Ubiquitin carboxyl-terminal hydrolase MINDY-1; TrEMBL-Plants: tr|I1LFY7|I1LFY7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0392000_LC | 7 | ||
| – | DNA-directed RNA polymerase III subunit RPC5; TAIR: AT5G49530.1 SIN-like family protein; Swiss-Prot: sp|Q76LS9|FA63A_MOUSE Ubiquitin carboxyl-terminal hydrolase MINDY-1; TrEMBL-Plants: tr|B9GW47|B9GW47_POPTR Uncharacterized protein; Found in the gene: LotjaGi2g1v0392000_LC | 7 | ||
| – | Protein FAM63A; TAIR: AT4G11860.1 FAM63A-like protein (DUF544); Swiss-Prot: sp|Q76LS9|FA63A_MOUSE Ubiquitin carboxyl-terminal hydrolase MINDY-1; TrEMBL-Plants: tr|A0A0L9UQ76|A0A0L9UQ76_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0430000 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |