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IPR007724

Source: InterPro

Description

IPR007724 is a Poly(ADP-ribose) glycohydrolase.

<p>Poly(ADP-ribose) glycohydrolase (PARG) ([ec:3.2.1.143]) is a ubiquitously expressed exo- and endoglycohydrolase which catalyses the hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, reversing the effects of poly(ADP-ribose) [[cite:PUB00064006], [cite:PUB00100178], [cite:PUB00100423], [cite:PUB00100425], [cite:PUB00100424]]. It generates mono-ADP-ribosylated proteins in cells, due to its ability of degrading poly(ADP-ribose) without cleaving the terminal protein-ribose bond [[cite:PUB00100423]]. PARG is also involved in the synthesis of nuclear ATP, which is required for extensive chromatin remodeling events [[cite:PUB00100426]]. This protein mediates oxidative and excitotoxic neuronal death [[cite:PUB00010199]].</p> <p>Arabidopsis thaliana PARG1 is involved in abiotic stress responses and DNA repair [[cite:PUB00100427], [cite:PUB00100428]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004649
Molecular function Poly(ADP-ribose) glycohydrolase activity Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
Subterm of
GO:0005975
Biological process Carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj1g3v0129720.1
– PREDICTED: poly(ADP-ribose) glycohydrolase 1-like [Glycine max] gi|356538602|ref|XP_003537791.1|
Domains
3
Lj1g3v0129780.1
– Poly(ADP-ribose) glycohydrolase [Medicago truncatula] gi|357457741|ref|XP_003599151.1|
Domains
3
Lj1g3v0129810.1
– PREDICTED: poly(ADP-ribose) glycohydrolase 1-like [Fragaria vesca subsp]. vesca] gi|470101453|ref|XP_004287187.1|
Domains
2
Lj1g3v3716220.1
– PREDICTED: poly(ADP-ribose) glycohydrolase 1-like [Glycine max] gi|356538602|ref|XP_003537791.1|
Domains
3
Lj6g3v0933480.1
– PREDICTED: poly(ADP-ribose) glycohydrolase 1-like [Glycine max] gi|356538602|ref|XP_003537791.1|
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 20.00